FEATURES OF STRUCTURAL-SPATIAL ORGANIZATION OF THE BLOOD СHANNELS OF RAT LUNG NORMALLY AND ITS REORGANIZATION IN GENERAL DEHYDRATION
DOI:
https://doi.org/10.11603/1811-2471.2018.v0.i3.9273Keywords:
experiment, norm, general dehydration, lungs, arteries, morphometryAbstract
Experimental animal modeling of various diseases is one of the main methods of studying the patterns of development of pathological processes that are common in clinical practice. At the same time, in order to objectively compare the experimental data and their subsequent extrapolation to a person, it is important to know the basic morphometric parameters of organs and tissues in the norm. As for general dehydration, it arises due to a wide variety of physiological and pathological conditions and can cause severe violations in various organs, including lungs.
The aim of the study – to determine the peculiarities of the structural and spatial organization of the blood channel of lungs of rats in norm and give a quantitative description of changes of its separate parameters at the general dehydration.
Material and Methods. Experiments were carried out on white laboratory sexually-mature male rats, which modeled general dehydration of different degrees of severity. The research was carried out using X-ray diffraction, histologic, morphometric and statistical techniques.
Results. According to the results of the study, certain specific peculiarities of the structural organization of the pulmonary tissue and the bloodstream of the lungs in the rats were determined and their quantitative assessment was made. These peculiarities include the ratio between right and left lungs by volume and mass, division each lung for lobes and the corresponding branching of their blood vessels. A peculiarity is also a rather frequent detection of arteries of the "locking" type. At prolonged general dehydration, ascending vasoconstriction with the simultaneous decrease in the throughput of branches of small and middle caliber pulmonary arteries and enlargement of the lumen and increase of capacity of intra-organ arteries of large caliber were noted.
Conclusions. 1. In rats, the right lung predominates much to the left in terms of volume and mass and their ratio is 2.22 to 1.00. 2. The peculiarity of the lungs of rats is their division into lobes: the right is divided into 4 lobes, the left lobe division is not expressed, which determines the features of the branching of the right and left pulmonary arteries. 3. Prolonged general dehydration leads to the decrease in the flow capacity of bloodstream of the lungs due to increased tone and narrowing of the lumen of the branches of the small and middle caliber pulmonary arteries, as well as of the bronchial arteries with the simultaneous enlargement of the lumen and the increase in the capacity of the intranasal arteries of large caliber.
References
Davidovskiy, I.V. (1962). Problema prichinnosti v meditsine (etiologiya) [Causation issues in medicine (etiology)]. Moscow: Medgiz [in Russian].
Sarkisov, D.S., & Remezov, P.I. (1960). Vosproizvedenie bolezney cheloveka v eksperimente [Experimental reproduction of human diseases]. Vishnevskiy, A.A. (Ed.). Moscow [in Russian].
Leytes, A., & Shidakov, Yu. (1972). Plastichnost krovenosnykh sosudov serdtsa i legkikh [Flexibility of blood vessels of the heart and lungs]. Kirgizstan: Frunze [in Russian].
Shlyakhover, V.E., Yabluchanskiy, N.I., & Shevchenko, V.I. (1983). Kolichestvennaya harakteristika strukturnoy organizatsii miokarda sobaki [Quantitative characteristics of the structural organization of the myocardium of a dog]. Krovoobrascheniye – Blood Flow, 16 (2), 3-6 [in Russian].
Schaper, G., Meiser, E., & Stammler, G (1985). Ultrastructural morphometric analysis of myocardium from dogs, rats, hamsters, mice and from human hearts. Circ. Res., 56 (3), 377-391.
Kiptenko, L.I., Vasko, L.V., & Hortynska, O.M. (2013). Morfolohichni zminy vnutrishnikh orhaniv shchuriv v umovakh klitynnoi dehidratatsii na tli postravmatychnoi reheneratsii velykohomilkovoi kistky [Morphological changes of internal organs of rats under condition of cell dehydration on the background of post-traumatic regeneration of tibia]. Svit medytsyny ta biolohii – World of Medicine and Biology, 2, 41-43 [in Ukrainian].
Netiukhailo, L.H., Filatova, V.L., & Filatova, O.V. (2012). Vodno-soliovyi obmin (ohliad literatury) [Water-salt metabolism (literature review)]. Visnyk problem biolohii i medytsyny – Journal of Problems of Biology and Medicine, 1 (91), 28-33 [in Ukrainian].
Sapozhnikov, O.P., & Maksymova, O.S. (2015). Morfolohichni i ultrastrukturni zminy u leheniakh shchuriv molodoho viku za umov vplyvu zahalnoi dehidratatsii [Morphological and ultrastructural changes in the lungs of rats of younger age under the impact of general dehydration]. Morfolohichni doslidzhennia – vyklyky suchasnosti. Zbirnyk tez dopovidei Naukovo-praktychnoi konferentsii – Morphological Studies – Challenges of Modernity. Collection of Reports of Scientific and Practical Conference. April 23-23, 2015. Sumy: Sumy State University [in Ukrainian].
Zaiko, M.N., & Bytsio, Yu.V. (Eds.). (2008).Patofiziolohiia [Pathophysiology]. Kyiv: Medytsyna [in Ukrainian].
Nahornaya, N.V. Seminar: toksikozy u detey [Seminar: toxicosis in children]. Zdorovye rebenka – Health of a Child, 1 (28), 7-15 [in Russian].
Bumeister, V.I. (2009). Elektronnomikroskopichna kartyna reheneratu velykohomilkovoi kistky shchuriv za dii pozaklitynnoho znevodnennia [Electromicroscopic image of the regenerate of rat tibia under the impact of extracellular dehydration]. Klinichna ta eksperymentalna patolohiia – Clinical and Experimental Pathology, 8 (2), 10-13 [in Ukrainian].
Guseynova, S.T. (2009). Morfologicheskie izmeneniya v imunnykh obrazovaniyakh tonkoy kishki pri degidratatsii i korrektsii fizrastvorom [Morphological changes in immune formations of small intestine under condition of dehydration and correction with physical solution]. Vestnik novykh meditsinskikh tekhnologiy – Journal of New Medical Technologies, 16 (2), 199-200 [in Russian].
Lepeyko, Yu.B., Nevzorova, V.A., & Gilifanov, E.A. (2015). Izmenenie aktivnosti neyrokininovoy sistemy v slizistoy obolochke verhnikh dykhatelnykh putey krys pri modelirovanii khronicheskogo tabakokureniya [Dynamics of neurokinin activity in the mucosa of upper respiratory tract of rats in modeling of chronic tobacco smoking]. Sibirskiy nauchnyy meditsinskiy zhurnal – Siberianm Scientific Medical Journal, 35 (1), 19-27 [in Russian].
