MORPHOLOGICAL CHANGES IN THE THYROID GLAND OF RATS UNDER CONDITIONS OF MODELED POSTRESECTION PORTAL HYPERTENSION
DOI:
https://doi.org/10.11603/1811-2471.2026.v.i2.16138Keywords:
thyroid gland, morphometry, postoperative portal hypertensionAbstract
SUMMARY. The thyroid gland is an organ with intensive blood supply and high metabolism, and various blood flow disorders lead to structural and functional changes in this organ. It is known that the structural and functional restructuring of the thyroid gland in hypertension in the hepatic portal vein system has not been studied in detail.
The aim – to morphometrically study the features of morphological reorganization of the thyroid gland structures in rats with experimental postoperative portal hypertension.
Material and Methods. The thyroid gland of three groups of sexually mature white male Wistar rats was morphologically examined: the first group – 15 control animals, the second – 32 rats with postoperative portal hypertension, the third – 15 animals with postresection portal hypertension complicated by multiple organ failure. Postresection portal hypertension was modeled by removing the left and right lateral lobes of the liver. A month after the start of the experiment, the rats were euthanized, the thyroid gland was isolated, and the area of the individual thyrocyte, its nucleus, nuclear-cytoplasmic index, volume of parenchyma, stroma, stromal-parenchymal ratios, and volume of damaged thyrocytes were determined on micropreparations. Quantitative data were processed statistically.
Results. It was found that the area of the thyroid thyrocyte in the conditions of postresection portal hypertension statistically significantly decreased (p<0.01) by 5.9 %, and with the development of multiple organ failure – by 9.8 %, the area of the nuclei, respectively – by 9.25 % and 17.8 % (p<0.001), the nuclear-cytoplasmic index also – by 7.36 % and 12.57 % (p<0.001), respectively. In the conditions of postresection portal hypertension, the stromal-parenchymal ratios in the thyroid gland increased by 35.6 %, with multiple organ failure – by 82.2 %, and the volume of damaged thyrocytes, respectively – by 7.16 times and 14 times (p<0.001).
Conclusions. It was found that prolonged postoperative portal hypertension led to a decrease in the size of thyrocytes, their nuclei, changes in nuclear-cytoplasmic ratios, an increase in stromal-parenchymal ratios, the volume of damaged thyrocytes, and a disruption of structural tissue and cellular homeostasis. The established structural changes of the studied organ dominated in the combination of postoperative portal hypertension and multiple organ failure.
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