TRIGLYCERIDES-GLUCOSE INDEX AS A SURROGATE MARKER OF INSULIN RESISTANCE IN PATIENTS WITH CORONARY ARTERY DISEASE, OVERWEIGHT AND OBESITY
DOI:
https://doi.org/10.11603/1811-2471.2018.v0.i3.8985Keywords:
insulin resistance, HOMA-IR index, triglyceride-glucose indexAbstract
There are many methods for evaluating insulin resistance (IR), but they have some disadvantages and high price. The Triglyceride-Glucose Index is a simple and clinically useful surrogate marker for insulin resistance, suitable for screening.
The aim: to evaluate the triglyceride-glucose index in patients with coronary artery disease and obesity, depending on insulin resistance; analyze correlations in the group of observed patients.
Material and Methods. The study included 107 patients with coronary artery disease, overweight or obesity. In all patients, glucose, insulin, HOMA-IR, HbA1c, lipids, uric acid and transaminases levels was measured, and calculated triglyceride-glucose indexes.
Patients were divided into 2 groups, depending on the level of HOMA-IR, insulin-resistance were patients who have HOMA-IR>1.7. Correlation analysis was performed in the whole population of patients.
Results. There were significantly higher glucose, insulin, triglycerides and uric acid levels in the group of patients with IR. A significantly higher triglyceride-glucose index in patients with insulin resistance and significant moderate positive relationship between HOMA-IR index and triglyceride-glucose index was identify.
Conclusions. The triglyceride-glucose index is a surrogate marker of insulin resistance, an accessible screening method for the identification of patients in need of an in-depth examination of glucose metabolism and its correction.
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