The influence of hyaluronic acid on the morphological peculiarities of the Granulation tissue of the laparotomic wound in using a continuous locking stitch
DOI:
https://doi.org/10.11603/2414-4533.2019.3.10471Keywords:
granulation tissue, laparotomy wound, continuous locking stitch, hyaluronic acidAbstract
The aim of the work: to investigate in the experiment the effect of topical application of hyaluronic acid on the morphological features of the granulation tissue of the laparotomy wound when suturing the last with continuous locking stitch.
Materials and Methods. An experiment was performed on 108 laboratory rats, which underwent a median laparotomy and reduced the edges of the musculoaponeurotic layer of the anterior abdominal wall with a continuous locking stitch. The animals of the main group were treated with a colorless transparent viscous hyaluronic acid gel on the suture line of the musculoaponeurotic layer. A sampling of biological material was performed on the 1st, 7th and 14th days after surgery.
Results and Discussion. It has been established that topical application of hyaluronic acid in the suturing of the edges of the musculoaponeurotic layer of the anterior abdominal wall by means of a continuous locking stitch leads to inhibition of the maturation of granulation tissue, since a marked decrease in the percentage of fibroblasts, plasmacytic cells and volume of blood vessels on the 14th day of observation.
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