STUDY OF HEPATOPROTECTIVE ACTION OF EXTRACTS FROM GARDEN PLUM FRUIT
DOI:
https://doi.org/10.11603/2312-0967.2018.4.9692Keywords:
plum fruit, dry extract with fibers, laxative activity, liverAbstract
The aim of the work. Studying the hepatoprotective activity of garden plum fruit dry extracts with fibers and polysaccharide complexes, which was evaluated by the activity of hepatospecific enzymes in serum, as well as on the parameters of protein metabolism, urea and total protein levels in blood of rats.
Materials and Methods. Alcoholic hepatitis was induced in rats by intragastric administration of 40 % ethanol at a dose of 7 ml/kg for 7 days. Plum fruit dry extracts were administered intragastrically at doses of 100 or 200 mg/kg. Aminotransferases, alkaline phosphatase (AP), γ-glutamyltranspeptidase activity, urea and total protein level were determined spectrophotometrically.
Results and Discussion. Experimental alcoholic hepatitis development was accompanied by a cytolytic syndrome and a hepatobiliary lesion. The urea level increased and total protein level decreased in blood. Dry extracts significantly lowered hepatospecific enzymes activity in blood serum, normalized urea and total protein levels at a dose of 200 mg/kg. We found that dry extract with fibers was the most active, and its effect was comparable to the reference drug silibor. Alkaline phosphatase activity reduction due to dry extracts with fibers administration indicated the stabilization of the functional state of the liver in rats, which is probably due to the content of the complex of polyphenolic compounds in it.
Conclusions. Significant hepatoprotective effect for dry extracts with fibers and polysaccharide complexes was showed. The dry extract with fibers was the most effective at a dose of 200 mg/kg.
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