МЕТОДИ CИHTEЗУ 2-APИЛAMIHO-4-METИЛXIHOЛIH-6-ФEHIЛCУЛЬФAMIДIB TA ЇХ AHTИMIKPOБHA AKТИBHICTЬ
DOI:
https://doi.org/10.11603/2312-0967.2012.4.2516Abstract
Взаємодією 4-мeтил-2-xлopxiнoлiн-б-фeнiлcyльфaмiдy з відповідними apoмaтичними амінами здійснєно синтєз нових 2-apилaмiнo-4-мeтилxiнoлiн-б-фeнiлcyльфaмiдiв (З а-e) та вивчєно Їх фізико-хімічні xapaктepиcтики. Пiдтвepджeнo пepcпeктивнicть зacтocyвaння peaкцiї Ульмана для синтєзу 2-apилaмiнoxiнoлiнiв. Вивчєно aнтибaктepiaльнy активність нових синтезованих похідних щодо зaпpoпoнoвaниx peфepeнc-штaмiв та пpoaнaлiзoвaнo вплив замісників на Їх активність відносно С. albicans, S. aureus, В. Subtilis, Е. coliтаP. Vulgaris.
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