ANALYSIS OF MULTICOMPONENT EXTEMPORAL DOSAGE FORM – QUATER MIXTURES
DOI:
https://doi.org/10.11603/2312-0967.2026.2.16334Keywords:
extemporaneous dosage forms, quality control., express analysis, titrimetry, Kvater's mixtureAbstract
The aim of the work. Scientific substantiation and development of methods for express analysis of a multicomponent dosage form of extemporaneous manufacture - Kvater's mixture, adapted for use in pharmacy settings.
Materials and Methods. For experimental studies, extemporaneously manufactured Kvater's mixture, electronic laboratory scales "RAD WAG AS 200/C", class A measuring vessels, porcelain cups, beakers, Mora pipettes (5.00 ml, 2.00 ml, 1.00 ml), a dividing funnel, a porcelain infusor, graduated pipettes (10 ml, 5 ml, 2 ml, 1 ml), and glass slides were used. The methodological basis of the work is titrimetric methods that were used to quantitatively determine the ingredients in the composition of the studied dosage form.
Results and Discussion. During the study, methods for rapid analysis of the multicomponent Kvater mixture were developed and tested, based on a combination of selective qualitative reactions and direct titration methods (argentometry, iodometry, complexometry and extraction alkalimetry). It was found that the use of preliminary extraction with methylene chloride and conducting a control experiment with a herbal infusion allows effectively eliminating the interfering effect of concomitant substances, ensuring high accuracy of quantitative determination of ingredients within the limits of permissible deviations in accordance with the requirements of the State Pharmacopoeia of Ukraine and Order of the Ministry of Health of Ukraine No. 812. The results obtained confirm the validity and expressness of the proposed control algorithms, which allows us to recommend them for implementation in the practice of pharmacies in order to optimize the pharmaceutical analysis of extemporaneous dosage forms.
Conclusions. The methods of express analysis of multicomponent extemporaneous Kvater's mixture have been systematized and tested, which, thanks to the combination of selectivity and efficiency, provide effective quality control in a pharmacy with minimal time consumption.
References
Ministry of Health of Ukraine. On approval of the Rules for the production (manufacturing) and quality control of medicinal products in pharmacies: Order of the Ministry of Health of Ukraine No. 812, 2012 Nov 2 [cited 2025 Sep 5]. Available from: https://zakon.rada.gov.ua/laws/show/z1846-12
State Enterprise "Ukrainian Scientific Pharmacopoeial Center for the Quality of Medicines". State Pharmacopoeia of Ukraine. 2nd ed. Suppl 7. Vol. 2. Kharkiv: State Enterprise "Ukrainian Scientific Pharmacopoeial Center for the Quality of Medicines"; 2024. 424 p.
Savchenko LP, Georgiyants VA. Current trends in compounding of medicines and its legislative regulation in foreign countries. Farmatsevtychnyi zhurnal. 2020;75(4):6-17. DOI: https://doi.org/10.32352/0367-3057.4.20.01 DOI: https://doi.org/10.32352/0367-3057.4.20.01
Moroz SG, Sahaidak-Nikitiuk RV. Research on modern trends in the development of the pharmaceutical industry of Ukraine. Social Pharmacy in Health Care. 2016;2(4):32-38. Available from: http://dspace.nuph.edu.ua/handle/123456789/12299 DOI: https://doi.org/10.24959/sphhcj.16.59
Lytvynenko LL, Sobkova AO. Prospects of development of the pharmaceutical market of Ukraine in the conditions of deepening of the EU integration process. Problems of Increasing the Efficiency of Infrastructure. 2015;40:51-57. Available from: http://nbuv.gov.ua/UJRN/ppei_2015_40_10
Samborskyi OS, Ievtushenko OM, Slobodyanyuk NN. Organization of pharmaceutical care in Ukraine: realities of extemporal medicines production. Pharmaceutical Review. 2017;4:87-98. DOI: 10.11603/23120967.2017.4.8337
Dankevych OS, Orlovetskaya NF. Modern prescription of soft drugs in pharmacies. Ukrainian Journal of Clinical and Laboratory Medicine. 2017;12(2):75-81. Available from: http://dspace.nuph.edu.ua/handle/123456789/18558
Downloads
Published
Issue
Section
License
This work is licensed under a Creative Commons Attribution 4.0 International License.
The authors who publish their materials in this journal agree with the following terms:
- Authors reserve the right to authorship of their work and assign to the journal the right to first publish this work under the terms of the Creative Commons Attribution License, which allows other persons to freely distribute the published work with a mandatory reference to the authors of original work and the first publication of work in this journal
. - Authors have the right to make independent extra-exclusive work agreements in the form they are published by this journal (for example, posting work in an electronic repository of an institution or publishing as part of a monograph), provided that the link to the first publication of the work in this journal is maintained.
Journal policy allows and encourages publication of manuscripts on the Internet (for example, in institutions repositories or on personal websites), both before the publication of this manuscript and during its editorial review, as it contributes to productive scientific discussion and positively affects the efficiency and dynamics of the citation of the published work (see The Effect of Open Access).
