SYNTHETIC APPROACHES FOR OBTAINING OF HETEROCYCLIC COMPOUNDS BASED ON THE [1,2,4]TRIAZOLO[3,4-b][1,3,4]THIADIAZOLE SYSTEM (A REVIEW)
DOI:
https://doi.org/10.11603/2312-0967.2025.3.15579Keywords:
triazolo[3,4-b][1,3,4]thiadiazoles, synthesis, chemical modificationAbstract
The aim of the work - to analyze of the literature data on methods for the synthesis of heterocyclic systems based on [1,2,4]triazolo[3,4-b][1,3,4]thiadiazole as promising objects for modern bioorganic and medicinal chemistry.
Materials and Methods. Information search, system and content analysis, generalization of results.
Results and Discussion. A review of modern literature sources was conducted, as a result of which resulted in analyzing on synthetic approaches to obtaining and the spectrum of pharmacological activity of heterocyclic systems based on [1,2,4]triazolo[3,4-b][1,3,4]thiadiazoles were analyzed. It was established that the specified framework as the main structural component is included in the composition of compounds with antimicrobial, anti-inflammatory, analgesic, antitumor, anti-tuberculosis and antiviral effects. Thus, the specified bicyclic scaffold can be considered as an important heterocyclic fragment, promising in terms of structural matrix for the construction of new drug-like molecules.
Conclusions. An analysis of the synthetic capacity and individual directions of chemical modification of triazolo[3,4-b][1,3,4]thiadiazole derivatives was carried out, which confirmed their versatile synthetic and pharmacological potential. Thus, it indicates the prospect of practical application in medicine and pharmacy.
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