SYNTHESIS OF THIAZOLIDINONE DERIVATIVES BASED ON CITRAL AS POTENTIAL BIOLOGICALLY ACTIVE COMPOUNDS
DOI:
https://doi.org/10.11603/2312-0967.2026.2.15977Keywords:
citral, thiazoles, thiazolidones, synthesis, ProTox-IIІAbstract
The aim of the work. To synthesize and investigate new thiazole and thiazolidinone derivatives containing a citral fragment, as well as to evaluate their predicted toxicity.
Materials and Methods. The synthesis of the target compounds was carried out using conventional organic synthesis methods. The structures of the obtained products were confirmed by 1H NMR spectroscopy and chromatography–mass spectrometry. For a selected set of synthesized compounds, in silico prediction of oral toxicity was performed using the ProTox-IIІ online platform.
Results. A series of thiazole and thiazolidinone derivatives incorporating a citral fragment into their molecular structure was successfully synthesized with high yields. The analysis of spectral data confirmed the proposed structures of the synthesized compounds. According to the toxicity prediction results, all investigated compounds belong to toxicity class IV (LD₅₀ = 350–1250 mg/kg) and predominantly do not exhibit hepatotoxic, immunotoxic, mutagenic, or cytotoxic effects. For some derivatives, a potential carcinogenic activity was predicted.
Conclusions. The synthesized thiazole and thiazolidinone derivatives containing a citral fragment are characterized by moderate predicted toxicity and may be considered promising molecular platforms for further pharmacological and toxicological studies.
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