CLINICAL CASE OF INTRAUTERINE MIXED INFECTION IN A NEWBORN

Authors

DOI:

https://doi.org/10.11603/1681-2727.2020.1.10783

Keywords:

newborn, congenital cytomegalovirus infection, sepsis, mixed infection

Abstract

The aim of the research. Тo analyze a clinical case of intrauterine mixed infection in a newborn.

In recent years, there has been an increase in the frequency and prevalence of intrauterine infections, which are leading in the structure of infant morbidity and mortality. Among these infections leading role takes the family of herpes viruses, which include cytomegalovirus (CMV). The ability of the virus to cause severe fetal damage is possible in any trimester of pregnancy, especially in cases of primary infection during pregnancy. Manifested congenital cytomegalovirus infection develops in 5–18 % of newborns and is characterized by severe course with high mortality. The virus has the ability to induce suppression of almost all parts of the immune system, namely: macrophage dysfunction, interleukin synthesis imbalance, inhibit T-lymphocyte activity, reduction in the ratio of CD4/CD8, the synthesis of interferons and the activity of natural killers, creates the prerequisites for the attachment of bacterial generalized infectious and inflammatory processes.

The article presents the features of the clinic and the course of intrauterine mixed infection in a newborn.

Author Biographies

  • N. M. Kretsu, Bukovinian State Medical University

    Assistant of the Department of Pediatrics and Children’s Infectious Diseasesof the Higher State Educational Establishment of Ukraine «Bukovinian State Medical University», Chernivtsi

  • L. V. Koliubakina, Bukovinian State Medical University

    PhD, Associate Professor of the Department of Pediatrics and Children’s Infectious Diseases of the Higher State Educational Establishment of Ukraine «Bukovinian State Medical University», Chernivtsi

References

Vasylenko, N. V., Volman, T. V. (2016). Congenital cytomegalovirus infection: practical aspects of the problem. Family Medicine, 2, 154-156 [in Ukrainian].

Kochkina, S. S., Sitnikova, E. P. (2013). Clinical “masks” of congenital cytomegalovirus infection in children. Bulletin of Modern and clinical Medicine, 6 (1), 31-33 [in Russian].

Barycheva, L. Yu., Golubeva, M. V., Kabulova, M. A. (2014). The formation of malformations in children with congenital cytomegalovirus infection. Fundamental Researches, 4-2, 237-241 [in Russian].

Krasnov, V. V., Obriadina, A. P. (2012). Clinical and laboratory characteristics of cytomegalovirus infection in children. Practical Medicine, 7, 137-139 [in Russian].

Golubeva, M. V. (2000). Clinical and immunological manifestations of congenital cytomegalovirus infection in children. Extended abstract of Doctor’s thesis. Moscow [in Russian].

Germanenko, I. G., Kudin, A. P. (2009). Cytomegalovirus infection in children. Minsk: BGMU [in Russian].

Published

2020-05-13

Issue

Section

Brief reports

How to Cite

CLINICAL CASE OF INTRAUTERINE MIXED INFECTION IN A NEWBORN. (2020). Infectious Diseases – Infektsiyni Khvoroby, 1, 64-67. https://doi.org/10.11603/1681-2727.2020.1.10783