THE CONTENT OF CADMIUM AND ZINC IN THE ECOSYSTEM OF CISCARPATHIAN REGION AND THE IMPACT OF CADMIUM INTOXICATION ON THE TRACE ELEMENT STATUS OF THE BODY OF EXPERIMENTAL ANIMALS

  • L. A. Nechitaylo THE CONTENT OF CADMIUM AND ZINC IN THE ECOSYSTEM OF CISCARPATHIAN REGION AND THE IMPACT OF CADMIUM INTOXICATION ON THE TRACE ELEMENT STATUS OF THE BODY OF EXPERIMENTAL ANIMALS
Keywords: heavy metals, soil, water, rat, kidney, liver, cadmium intoxication

Abstract

Introduction. Among the measures that should ensure the protection of human health and the environment of its habitat from man-made metals, control over the level of metal content in soil, water, human organism and animals plays an important role.

The aim of the study – to carry out a comparative analysis of the level of cadmium and zinc in the soils and reservoirs of the plain, foothill and mountainous areas of the Precarpathian region, as well as the study of the influence of cadmium intoxication on the microelement composition of the liver and kidneys of experimental animals.

Research Мethods. The object of research was the soils and reservoirs of different geographical zones of Ciscarpathian. Cadmium intoxication was modeled on white male rats, which were divided into two groups: the control and the experimental, which intramuscularly injected cadmium chloride in a dose of 1/10 LD50. The concentration of trace elements in the objects of the environment, organs and tissues of experimental animals was determined by the atomic absorption spectrophotometry method on a spectrophotometer C - 115 PC.

Results and Discussion. The paper presents the results of the content of cadmium and zinc in the soil and drinking water of the plain, foothill and mountainous regions of the region. It was established that in the soil the level of cadmium and zinc in all investigated zones is within the limits of normative indicators. However, the results on the control of cadmium in drinking water indicates an increase in the concentration of cadmium in excess of the maximum permissible norms by 1.5–2 times in plain and foothill areas, and the minimum level – in mountainous areas. Such results encourage the study of the effects of cadmium intoxication on the body of experimental animals. The obtained data indicate that in the body of experimental animals, which continued to drink potable water with high cadmium content there is accumulation in the liver and kidneys of cadmium.

Conclusions. Significant differences in the content of cadmium and zinc in soils and water of the plain, foothill and mountainous areas of the Carpathian region are established. It has been determined that in the organism of experimental animals, cadmium intoxication leads to accumulation of cadmium in the liver and kidneys, which is accompanied by a violation of the level of essential elements of zinc and copper.

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Published
2019-02-01
How to Cite
Nechitaylo, L. (2019). THE CONTENT OF CADMIUM AND ZINC IN THE ECOSYSTEM OF CISCARPATHIAN REGION AND THE IMPACT OF CADMIUM INTOXICATION ON THE TRACE ELEMENT STATUS OF THE BODY OF EXPERIMENTAL ANIMALS. Medical and Clinical Chemistry, (4), 60-65. https://doi.org/10.11603/mcch.2410-681X.2018.v0.i4.9797
Section
ORIGINAL INVESTIGATIONS