The role of lipid peroxidation and antioxidant protection for development pathogenesis of experimental bronchial asthma and adrenaline myocardial damage

  • M. S. Reheda
  • N. M. Nebelyuk
Keywords: malondialdehyde, diene conjugates, superoxide dismutase, catalase, glutathione reductase.

Abstract

The paper examined the role of lipid peroxidation (LP) and antioxidant protection in the miocardium of guinea pigs in experimental asthma (EA) in combination with adrenaline myocardial damage (AMD). Analyses were performed on the 1st, 4th, 18th and 25th day. The results showed that at all stages of the development ofEAwithAMD increased content of lipid peroxidation products (diene conjugates and malondialdehyde), while at the same time on the 1st and 4th day increases the activity of superoxide dismutase, catalase and glutathione reductase in the miocardium, followed by reduction in their on the 18th and 25th day.

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Published
2016-05-12
How to Cite
Reheda, M. S., & Nebelyuk, N. M. (2016). The role of lipid peroxidation and antioxidant protection for development pathogenesis of experimental bronchial asthma and adrenaline myocardial damage. Medical and Clinical Chemistry, (2), 59-62. https://doi.org/10.11603/mcch.2410-681X.2016.v0.i2.6673
Section
ORIGINAL INVESTIGATIONS