INDICATORS OF ENDOGENOUS INTOXICATION IN RATS WITH BENIGN PROSTATIC HYPERPLASIA UNDER TOXIC EFFECT OF ETHANOL
DOI:
https://doi.org/10.11603/mcch.2410-681X.2021.i4.12727Keywords:
ethanol, endogenous intoxication, benign prostatic hyperplasiaAbstract
Introduction. Benign prostatic hyperplasia (BPH) occupies an important place among urological diseases of older men with a tendency to increase. The most common social problem is alcohol consumption. Its toxic effects are found in many systems and organs, because it easily interacts with many processes of the body. Due to the syndrome of endogenous intoxication, we can evaluate a lot of data and get results on the course of many diseases by the level of middle mass molecules and changes in erythrocyte index.
The aim of the study – to analyze the changes in endogenous intoxication by the level of middle mass molecules and changes in erythrocyte index in rats with benign prostatic hyperplasia with combined action of ethanol.
Research Methods. The experimental animals were divided into 4 groups: Group I (control group) rats, which were injected for 28 days with distilled water orally; Group II – which for 28 days were injected with ethanol 40 % ethanol solution at a rate of 2 ml/100 g of body weight orally 1 time per day. In animals of group III, the development of BPH was simulated by subcutaneous administration of ampule 5 % testosterone at a dose of 0.1 mg/kg once a day for 28 days; Group IV (12 animals) – reproduced a model of BPH with additional toxic effects of 40 % ethanol solution at the rate of 2 ml/100 g of body weight orally once a day for 28 days.
Results and Discussion. As a result of studies we conducted in animals of different experimental groups under the conditions of experimental modeling of benign prostatic hyperplasia, it was found that there is a gradual increase in endogenous intoxication on day 7, 14, 21 of the experiment. All EI markers reached the highest values on day 21 of the study.
Conclusion. Therefore, we were able to identify significant changes and disturbances of intoxication in animals under the toxic action of ethanol, which is important for their pathogenesis.
References
Yakovlyeva, L.V., & Muzyka, N.Ya. (2009). Benign prostatic hyperplasia, diagnosis and treatment (literature review). Clinical Pharmacy, 13 (4), 66-70 [in Ukrainian].
Romanyuk, A.M., & Shkrobav, O.A. (2014). Morphogenesis of the prostate gland of rats in the age aspect. Ukrainian Morphological Almanac, 12 (2), 79-81 [in Ukrainian].
Mobley, D., Feibus, A., & Baum, N. (2015). Benign prostatic hyperplasia and urinary symptoms: Evaluation and treatment. Postgrad. Med., 127, 301-307. DOI: 10.1080/00325481.2015.1018799
Kharchenko, O., Ostapchenko, H., & Havrysh, L. (2006). Toxic effect of ethanol and its products on the body. Bulletin of the NAS of Ukraine, 3, 57-64 [in Ukrainian].
Voloshyna, I.S. (2011). Modern ideas about the morphogenesis of the internal organs of the male reproductive system under the influence of various factors. Ukrainian Morphological Almanac, 9, 4, 155-160 [in Ukrainian].
Mazur, O.O., Olenovych, O.A., Plaksyvyy, O.H., Kalutskyy, I.V., Yakovets, K.I., & Bohach, V.A. (2017). Indicators of endogenous intoxication in patients with chronic purulent maxillary sinusitis with type 1 diabetes mellitus. Bukovinian Medical Bulletin, 21, 1 (81), 76-80 [in Ukrainian].
Klishch, I.M., & Khorosh. V.Ya. (2013). Indicators of endogenous intoxication and humoral immunity in animals with chronic prostatitis and benign hyperplasia on the background of simultaneous exposure to toxic xenodermal extract. Medical Chemistry, 15 (1), 125-129 [in Ukrainian].
Lys, O.B., & Reheda, M.S. (2019). The degree of endogenous intoxication in the dynamics of combined pathology – immobilization stress and adrenaline damage to the myocardium. Bulletin of Scientific Research, 1, 131-134 [in Ukrainian].
Khokhlova, N.I., Tolokonskaya, N.P., & Pupyshev, A.B. (2011). Multifactor clinical and laboratory evaluation of endogenous intoxication in chronic hepatitis B. Bulletin of Siberian Medicine, 3, 139- 145 [in Russian].
Aksenova, M.V., Kuznetsov, V.F., & Maslov, Yu.N. (2005). [Laboratory diagnosis of endogenous intoxication syndrome: Guidelines]. Perm: PGMA [in Russian].
Volchegorskiy, I., Dyatlov, D.A., & Lvovskaya, Ye.I. (1996). [Medium molecules as probable regulators of the erythron system in skiers]. Human Physiology, 22 (3), 136-137 [in Russian].
Kazimirko, V.K., & Maltsev, V.I. (2007). Antioxidant system and its functioning in the human body. Health of Ukraine, 5, 15-24 [in Russian].
Drannik, G.N. (1999). Clinical immunology and allergology. Odesa: AtroPrint [in Russian].
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2022 Medical and Clinical Chemistry
This work is licensed under a Creative Commons Attribution 4.0 International License.
