CORRELATIVE RELATIONS BETWEEN ADIPOKINES AND INSULIN RESISTANCE IN WOMEN WITH THE POLYCYSTIC OVARY SYNDROME AND OBESITY
DOI:
https://doi.org/10.11603/24116-4944.2018.2.9541Keywords:
leptin, adiponectin, insulin resistance, polycystic ovary syndromeAbstract
The aim of the study – to define the correlation between adipokines and insulin resistance (IR) indices by studying the content of leptin and adiponectin in the blood of women with polycystic ovary syndrome (PCOS).
Materials and Methods. 45 patients with PCOS have been examined. Control group involved 20 healthy women. The study investigated the levels of leptin and adiponectin, hormonal markers of hyperandrogenemia and parameters of insulin resistance in women's blood. Hormones and adipokines have been identified with ECLIA immunoassay together with automatic analyzers and reagents from Roche Diagnostics (Germany). besity was verified by the body mass index (BMI). IR was evaluated by NOMA index.
Results and Discussion. Obese patients with PCOS experience hyperleptinemia and hypoadiponectinemia, increasing directly proportional to their BMI. The high concentration of leptin positively correlates with IR parameters. In a group of women with PCOS we haven’t identified any statistically significant correlations between serum adiponectin concentration and hormonal indices. However, there has been identified a significant negative relationship between the concentration of adiponectin and BMI in the blood serum.
Conclusions. Hyperleptinemia and hypoadiponectinemia arising as a result of obesity, trigger the development of IR and hyperinsulinemia, which stimulates steroidogenesis in the theca cells of the ovary, provokes dysfunction in the hypothalamus-pituitary-ovarian system and leads to the development of PCOS. Adipokines (leptin and adiponectin) can serve as a link with which obesity and IR provoke the PCOS development as well as the sexual and reproductive dysfunctions in women.
References
Andreyeva, Ye.N., Semicheva, T.V., & Vesnina, A.F. (2007). Molekulyarno-geneticheskiye aspekty patogeneza sindroma polikistoznykh yaichnikov [Molecular genetic aspects of the pathogenesis of polycystic ovary syndrome]. Problemy reproduktsii – Problems of Reproduction, 13, 6, 29-35 [in Russian].
Bikmeyeva, A.A., & Karyagina, N.T. (2018). Vliyaniye leptina i adiponektina na narusheniya reproduktivnoy funktsii u zhenshchin pri ozhirenii [The effect of leptin and adiponectin on impaired reproductive function in women with obesity]. Mezhdunarodnyy studencheskiy nauchnyy vestnik – International Student Scientific Journal, 4, 3-7 [in Russian].
Grodnitskaya, Ye.E, & Kurtser, M.A. (2012). Antimyullerovyy gormon kak marker stepeni ovulyatornoy disfunktsii u zhenshchin s sindromom polikistoznykh yaichnikov [Anti-Muller hormone as a marker of the degree of ovulatory dysfunction in women with polycystic ovary syndrome]. Zhurnal akusherstva i zhenskikh bolezney – Journal of Obstetrics and Female Diseases, 1, 102-104 [in Russian].
Guriyev, T.D. (2010). Sindrom polikistoznykh yaichnikov [Polycystic ovary syndrome]. Akusherstvo i ginekologiya. Reproduktologiya. – Obstetrics and Gynecology. Reproductology, 4, 2, 10-15 [in Russian].
Dedov, I.I., Melnichenko, G.A., & Butrova, S.A. (2017). Zhirovaya tkan kak endokrinnyy organ [Adipose tissue as an endocrine organ]. Ozhireniye i metabolizm / Federalnoye gosudarstvennoye byudzhetnoye uchrezhdeniye Endokrinologicheskiy nauchnyy tsentr Ministerstva zdravookhraneniya Rossiyskoy Federatsii - Obesity and Metabolism / Federal State Budgetary Institution Endocrinological Research Center of the Ministry of Health of the Russian Federation], 1, 6-13 [in Russian].
Kamayeva, I.A., Pavlov, D.S., & Kazmin, A.S. (2016). Ozhireniye kak prichina narusheniya reproduktivnoy funktsii [Obesity as a cause of impaired reproductive function]. Molodoy uchenyy – Young Scientist, 26, 18-20 [in Russian].
Kaminskiy, V.V., Tatarchuk, T.F., & Dubossarska, Yu.O. (2016). Natsionalnyi konsensus shchodo upravlinnia patsiientamy z hiperandrohenizmom [The national consensus of the governance of the parasitic enterprises]. Reproduktyvna endokrynolohiia – Reproductive Endocrinology, 4 (30), 19-31 [in Ukrainian].
Kovaleva, O.V. (2014). Rol ozhireniya v razvitii narusheniy menstrualnoy i reproduktivnoy funktsii [The role of obesity in the development of menstrual and reproductive disorders]. Rossiyskiy vestnik akushera-ginekologa – Russian Bulletin of the Obstetrician-Gynecologist, 14, 2, 43-51 [in Russian].
Manukhin, I.B., Gevorkyan, M.A., & Chagay, N.B. (2006). Anovulyatsiya i insulinorezistentnost [Anovulation and insulin resistance]. Moscow: GEOTAR-Media [in Russian].
Tatarchuk, T.F., Voronenko, N.Yu., & Kapshuk, I.M. (2013). Stan zhyrovoi tkanyny pry polikistoznomu syndromi yaiechnyka [Status of adipose tissue in polycystic ovary syndrome]. Zdorovia zhinky – Women's Health, 10, 35-38 [in Ukrainian].
Urbanovych, A.M. (2013). Hormony zhyrovoi tkanyny ta ikh klinichne znachennia [Hormones of adipose tissue and their clinical significance]. Endokrynolohiia – Endocrinology, 18 (1), 69-72 [in Ukrainian].
Santos, E.D., Santos-Reis, M., Rosalino, L.M., & Ustin, S.L. (2012). Adiponectin and Reproduction. Vitam. Horm., 90, 187-209.
Amato, M.C., Guarnotta, V., Forti, D., Donatelli, M., Dolcimascolo, S., & Giordano, C. (2013). Metabolically healthy polycystic ovary syndrome (MH-PCOS) and metabolically unhealthy polycystic ovary syndrome (MU-PCOS): a comparative analysis of four simple methods useful for metabolic assessment. Hum. Reprod,. 28 (7), 1919-1928.
Bachelot, A. (2016). Polycystic ovarian syndrome: clinical and biological diagnosis. Ann. Biol. Clin. (Paris), 1, 74 (6), 661-667.
Conway, G.S., Dewailly, D., Diamanti-Kandarakis, E., Escobar-Morreale, H.F., Franks, S., Gambineri, A., ... & Yildiz, B.O. (2014). The polycystic ovary syndrome: an endocrinological perspective from the European society of endocrinology. Eur. J. Endocrinol., 171, 489-498.
Farrell, R., & Antoni, M.N. (2010). Insulin resistance, obesity, inflammation and depression in polycystic ovary syndrome: biobehavioral mechanisms and interventions. Fertil. Steril, 94, 1565-1574.
Galic, S., Oakhill, J.S., & Steinberg, G.R. (2010). Adipose tissue as endocrine an organ. Molecular and Cellular Endocrinology, 316, 2, 129-139.
Legro, R.S., Arslanian, S.A., Ehrmann, D.A., Hoeger, K.M., Murad, M.H., Pasquali, R., & Welt, C.K. (2013). Diagnosis and treatment of polycystic ovary syndrome: An endocrine society clinical practice guideline. Journal of Clinical Endocrinology and Metabolism, 98 (12), 4565-4592. DOI: 10.1210/jc.2013-2350.
Oh, J.Y., Sung, Y.A., & Lee, H.J. (2013). The visceral adiposity index as a predictor of insulin resistance in young women with polycystic ovary syndrome. Obesity, 21, 1690-1694.
(2004). Rotterdam ESHRE/ASRM-Sponsored PCOS consensus workshop group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to Polycystic Ovary Syndrome (PCOS). Hum. Reprod., 19 (1), 41-47.
Michalakis, K., Mintziori, G., Kaprara, A., Tarlatzis, B.C., & Goulis, D.G. (2013). The complex interaction between obesity, metabolic syndrome and reproductive axis: a narrative revive. Metabolism, 62, 4, 457-478.
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