COMPREHENSIVE APPROACH TO THE TREATMENT OF TUBO-PERITONEAL INFERTILITY IN WOMEN WITH COMBINED VULVOVAGINAL AND CERVICAL INFECTIONS
DOI:
https://doi.org/10.11603/24116-4944.2025.1.15407Keywords:
infertility, vulvovaginal infections, cervical infections, diagnosis, treatment optimization, reproductive function, ozone therapyAbstract
The aim of the study – to assess the impact of urogenital infections on female reproductive function and to develop an effective, individualized treatment algorithm incorporating ozone therapy as a promising adjuvant method.
Materials and Methods. The study involved 150 women of reproductive age diagnosed with infertility (both primary and secondary forms). All participants underwent comprehensive clinical, instrumental, microbiological, and immunological examinations. The main group consisted of 75 women who, in addition to standard treatment, received ozone therapy (vaginal instillations and ozone-oxygen infusions), while the control group of 75 patients received only conventional antibacterial and anti-inflammatory therapy.
Results and Discussion. Analysis of the results demonstrated that the inclusion of ozone therapy led to a significant improvement in clinical outcomes: the pregnancy rate within six months after treatment was 47 % in the main group versus 18 % in the control group, reflecting a 2.6-fold increase in treatment effectiveness (p<0.01). Furthermore, normalization of the vaginal microbiota, reduction in pro-inflammatory cytokine levels, and improvement in local immune parameters were observed.
Conclusions. These findings confirm the clinical value of incorporating ozone therapy into comprehensive treatment protocols for infection-related infertility as an effective and pathogenetically justified therapeutic component capable of significantly improving reproductive outcomes.
References
1. Leli, C., Mencacci, A., Latino, M. A., & Clerici, P. (2018). Mycoplasma hominis and Mycoplasma genitalium in childbearing age women by a commercially available multiplex real-time PCR: An Italian observational multicentre study. Journal of Infection and Public Health, 11(5), 713–718. https://doi.org/10.1016/j.jiph.2018.04.002
2. Ravel, J., & Simón, C. (2021). Bacterial vaginosis and its association with infertility, endometritis, and pelvic inflammatory disease. American Journal of Obstetrics and Gynecology, 224(1), 22–29. https://doi.org/10.1016/j.ajog.2020.08.101
3. Busnelli, A., Garolla, A., Tersigni, C., Parodi, V., Inversetti, A., Levi-Setti, P. E., … & Di Simone, N. (2023). Sperm human papillomavirus infection and risk of idiopathic recurrent pregnancy loss: Insights from a multicenter case-control study. Fertility and Sterility, 119(2), 378–386. https://doi.org/10.1016/j.fertnstert.2022.10.014
4. Wójkowska-Mach, J., Pomorska-Wesołowska, M., Romanik, M., & Romaniszyn, D. (2021). Prevalence and antimicrobial susceptibility profiles of microorganisms associated with lower reproductive tract infections in women. International Journal of Environmental Research and Public Health, 18(1), 335. https://doi.org/10.3390/ijerph18010335
5. Yazdy, G. M., Van Gerwen, O. T., Ghanem, K. G., Sobel, J. D., Tuddenham, S., & Muzny, C. A. (2023). Testing for Mycoplasma genitalium in women with vaginal symptoms should not be performed routinely. Sexually Transmitted Diseases, 50(10), 707–711. https://doi.org/10.1097/OLQ.0000000000001837
6. Zhang, Z., Zong, X., Bai, H., Fan, L., Li, T., & Liu, Z. (2023). Prevalence of Mycoplasma genitalium and Chlamydia trachomatis in Chinese females with lower reproductive tract infection: A multicenter epidemiological survey. BMC Infectious Diseases, 23(1), 25. https://doi.org/10.1186/s12879-022-07922-4
7. Peuchant, O., Lhomme, E., Krêt, M., Ghezzoul, B., Roussillon, C., Bébéar, C., … & de Barbeyrac, B. (2019). Randomized, open-label, multicenter study of azithromycin compared with doxycycline for treating anorectal Chlamydia trachomatis infection. Medicine (Baltimore), 98(7), e14402. https://doi.org/10.1097/MD.0000000000014402
8. Ma, C., Du, J., Dou, Y., Chen, R., Li, Y., Zhao, L., … & Zhang, K. (2021). The associations of genital mycoplasmas with female infertility and adverse pregnancy outcomes: A systematic review and meta-analysis. Journal of Assisted Reproduction and Genetics, 38(1), 35–49. https://doi.org/10.1007/s10815-020-01974-z
9. Cao, D. Y., Yang, J. X., Wu, X. H., Chen, Y. L., Li, L., Liu, K. J., … & Shen, K. (2013). Comparisons of vaginal and abdominal radical trachelectomy for early-stage cervical cancer: Preliminary results of a multi-center research in China. British Journal of Cancer, 109(11), 2904–2910. https://doi.org/10.1038/bjc.2013.654
10. Slama, J., Runnebaum, I. B., Scambia, G., Angeles, M. A., Bahrehmand, K., Kommoss, S., … & Cibula, D. (2023). Analysis of risk factors for recurrence in cervical cancer patients after fertility-sparing treatment. American Journal of Obstetrics and Gynecology, 229(2), 1–9. https://doi.org/10.1016/j.ajog.2023.01.014
Downloads
Published
Issue
Section
License
Copyright (c) 2025 О. В. Горбунова, С. В. Нагірняк
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish in this journal agree to the following terms:
1. The authors reserve the right to authorship of the work and pass the journal right of first publication of this work is licensed under a Creative Commons Attribution License, which allows others to freely distribute the work published with reference to the authors of the original work and the first publication of this magazine.
2. Authors are entitled to enter into a separate agreement on additional non-exclusive distribution of work in the form in which it was published in the magazine (eg work place in the electronic repository institution or publish monographs in part), provided that the reference to the first publication of this magazine.
3. Policy magazine allows and encourages authors placement on the Internet (eg, in storage facilities or on personal websites) manuscript of how to submit the manuscript to the editor and during his editorial processing, since it contributes to productive scientific discussion and positive impact on the efficiency and dynamics of citing published work (see. The Effect of Open Access).
