PREVENTION OF PREGNANCY LOSS IN WOMEN WITH OVARIAN HYPERSTIMULATION SYNDROME IN ASSISTED REPRODUCTIVE TECHNOLOGIES (ART) PROGRAMS
DOI:
https://doi.org/10.11603/24116-4944.2025.1.15406Keywords:
оvarian hyperstimulation syndrome, assisted reproductive technologies, individualized stimulation, dual trigger, freeze-all strategy, luteal phase support, dopamine agonists, clinical pregnancyAbstract
The aim of the study – to evaluate the clinical efficacy of individualized ovarian stimulation protocols and modern strategies in prevention of ovarian hyperstimulation syndrome (OHSS) in improving pregnancy outcomes and reducing complication rates in high-risk patients.
Materials and Methods. A randomized prospective trial was conducted involving 120 women at high risk of OHSS. Participants were divided into a control group (standard stimulation) and an intervention group, where an individualized approach was used. The latter included GnRH-antagonist protocols, dual trigger ovulation, enhanced luteal phase support, administration of cabergoline, and a freeze-all strategy.
Results and Discussion. Application of the personalized stimulation strategy significantly reduced the incidence of OHSS (3.3 % vs. 16.7 %), increased the clinical pregnancy rate (50 % vs. 35 %), and lowered early miscarriage rates (10 % vs. 20 %) compared to the standard approach.
Conclusions. Individualized ovarian stimulation protocols in ART programs are clinically effective for both OHSS prevention and improving reproductive outcomes in women with increased risk.
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