PATTERN OF EARLY GESTATIONAL COMPLICATIONS IN PREGNANT WOMEN WITH CHRONIC GASTRITIS
DOI:
https://doi.org/10.11603/24116-4944.2018.2.9606Keywords:
pregnancy, early gestational complications, chronic gastritisAbstract
The aim of the study – to determine the pattern and frequency of early gestational complications in pregnant women with chronic gastritis based on the retrospective analysis.
Materials and Methods. A clinical and statistical analysis was performed based on the results of the evaluation of medical records of 200 pregnant women, including 100 women (group 1) with chronic gastritis and 100 patients (group 2) without chronic gastritis. The analysis assessed social, gynecological, reproductive history, consequences of previous pregnancies, past diseases, and evaluated the course of current pregnancy and pregnancy outcome. Statistical analysis of the results was performed with MedStat (2004–2017) package. Mean value and standard deviation of a parameter were calculated for quantitative assessment, and Student’s test was used for comparison between groups. For qualitative assessment, the frequency of a parameter (%) was calculated, and frequencies were compared using the chi-square test. The relative risk (RR) and its 95 % confidence interval (95 % CI) were calculated for the quantitative assessment of the clinical effect. The critical significance level was 0.05.
Results and Discussion. The age of pregnant women ranged from 19 to 45 years. The average age was (29.8 ± 5.6) years in pregnant women with chronic gastritis, and (30.5±5.9) years in group 2 with no statistically significant difference (p˃0.005). There were 30.0 % of primigravidas and 70.0 % of multigravidas in group 1 and 44.0 % and 56.0 % in group 2, respectively. When comparing the data of gynecological and reproductive history, no statistically significant differences between the groups were found (p>0.05). The frequency and the pattern of extragenital pathology in two groups were comparable (p<0.05 for all pathologies). Based on the analysis of the pattern and frequency of early gestational complications in two groups, a statistically significantly (p=0.006) higher frequency of early gestosis manifestations (emesis gravidarum) was found for patients of group 1. The frequency of threatened miscarriage was higher for patients with chronic gastritis (p = 0.04), RR = 2.0 (95 % CI 1.1–3.8) compared with patients without chronic gastritis. The frequency of miscarriage was also higher (P <0.001), RR = 8.5 (95 % CI 3.1–23) in pregnant women of group 1, compared with patients of group 2. No statistically significant difference in stillbirth frequency was found (p>0.05).
Conclusion. Pregnant women with chronic gastritis have significantly higher frequency of early gestational complications, especially emesis gravidarum, threatened miscarriage and spontaneous abortion compared with pregnant women without gastritis.
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