STATUS OF FAGOCYTOSIS IN EXPERIMENTAL ANIMALS IN ADRENALINE MYOCARDIOPATHY
DOI:
https://doi.org/10.11603/2415-8798.2018.4.9611Keywords:
adrenalin myocardiopathy, normergic, hypoergic, hyperergic ran across inflammatory reactionAbstract
Taking into account the high prevalence of cardiovascular diseases in the world, earlier studies of the peculiarities of the metabolism and structure of the myocardium when damaged by its adrenaline insufficiently reveal the state of immune responses, in particular the role of phagocytes in the development of adrenergic myocardial damage when the body reactivity changes.
The aim of the study – to learn the state of phagocytosis in the development of adrenal myocardial infection in animals with different types of inflammatory response.
Materials and Methods. Experiments were conducted on 60 non-linear male rats weighing 180–200 g, divided into three groups: group 2 – 18 white rats with adrenal myocardial infarction; group 2 – 18 white rats, in which adrenal myocardial infarction was induced in the background of hypoergic inflammatory reaction; the group 3 – 18 white rats, in which adrenal myocardial infarction was caused by a hyperergic inflammatory reaction. Phagocytic activity of leukocytes was determined by two indicators: the percentage of phagocytic leukocytes and phagocytic number.
Results and Discussion. For the normal course of an inflammatory reaction, the phagocyte count decreased significantly only for 24 hours of development of adrenal myocardial infarction with a 7-day recovery. During the hyperergic course of the inflammatory reaction, the depression of the activity of phagocytes, which arose already for 1 year of development of adrenal myocardial infarction, decreased somewhat for 24 hours, and at 7 days the activity of leukocytes was restored.
Conclusions. For all types of inflammatory response of the body, the phagocytic activity of leukocytes is suppressed in the development of adrenal myocardial infarction, as evidenced by a decrease in phagocytic number. The intensity of such changes is most significant in the hypoergic course of the inflammatory reaction. By the indicator of the percentage of phagocytic leukocytes there was a decrease from the index of intact animals in all terms of observation.
References
Internet resource. Retrieved from: http://www.who.int/cardiovascular_diseases.
Terenda, N.O. (2015). Smertnist vid sertsevo-sudynnykh zakhvoriuvan yak derzhavna problema [Mortality from cardiovascular diseases as a state problem]. Visnyk naukovykh doslidzhen – Bulletin of scientific researches, (4), 11-13 [in Ukrainian].
Boykiv, A.B. (2012). Stan membrano-ruinivnykh protsesiv u krovi shchuriv z riznym typom zapalnoi reaktsii pislia vvedennia kardiotoksychnoi dozy adrenalinu [State of membrane-destructive processes in the blood of rats with different types of inflammatory reaction after administration of the cardiotoxic dose of adrenaline]. Ukrayinskyi medychnyi almanakh – Ukrainian Medical Almanac, (15), 5 (dodatok), 38-39 [in Ukrainian].
Boykiv, A.B. (2008). Ultrastrukturni zminy miokarda shchuriv pry hipoerhichnomu ta hipererhichnomu perebihu adrenalinovoi miokardiopatii v eksperymenti [Ultrastructural changes in myocardial rats in gipoergic and hyperergic epinephrine myocardiopathy in the experiment]. Svit medytsyny i biolohii – World of Medicine and Biology, (2), р II, 15-20 [in Ukrainian].
Markova, Ye.A., & Misula, I.R. (1992). Pokazately sostoyanyya perekysnoho okyslenyya lypydov v serdechnoy myshtse vzroslykh y starykh zhyvotnykh pry razvytyy adrenalynovoy myokardyodystrofyy [Indicators of lipid peroxidation in the heart muscle of adults and old animals during the development of adrenaline myocardiodystrophy]. Problemy stareniya i dolgoletiya – Problems of aging and longevity, (1), 14-16 [in Russian].
Mysula, I.R., & Vayda, O.V. (2003). Zahoiennia kuksy bronkha pislia pulmonektomii u tvaryn z riznoiu reaktyvnistiu [Harvesting of bronchus kukes after pulmonectomy in animals with different reactivity]. Zdobutky klinichnoi i eksperymentalnoi medytsyny – Achievements of clinical and experimental medicine, (1), 147 [in Ukrainian].
Kuznetsova, L.V., Babadzhan, V.D., Kharchenko, N.V., Prylutskyi, O.S., Harnyk, T.P., Piletskyi, A.M., & Mashenska, T.V. (2013). Imunolohiya: pidruchnyk [Immunology: textbook]. In Kuznetsova, L.V., Babadzhan, V.D., & Kharchenko, N.V. (Eds.). Vinnitsa : TOV «Merkiuri Podillia», (p. 86-88) [in Ukrainian].
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