FEATURES OF MORPHOFUNCTIONAL ALTERATION OF BLOOD VESSELS OF THE KIDNEYS UNDER CONDITION OF ACUTE POISOING OF ACETYLSALICYLIC ACID
DOI:
https://doi.org/10.11603/2415-8798.2018.3.9418Keywords:
acetylsalicylic acid, kidneys, arteries, veinsAbstract
As you know, the kidneys play an important detoxification role in the body. All poisonous substances that enter the body are derived from it, mainly in three ways: filtration, excretion and secretion. One such substance is acetylsalicylic acid. Its toxic effects in large doses and, if used erroneously, can lead to severe poisoning, often with lethal consequences. Moreover, the prevalence of aspirin-containing anesthetic products that are found in almost every household makes them commonly available sources of unintentional and suicidal admission. In particular, the use of salicylates continues to be a frequent cause of poisoning in children and teenagers.
The aim of the study – to determine the features of morphofunctional reorganization of blood vessels of the kidneys under severe acute poisoning with acetylsalicylic acid of a severe degree and their quantitative characteristics.
Materials and Methods. Experiments were performed on 24 white laboratory mature male rats. Among them 12 animals were in control group; another 12 rats received once a day pre-gastric acetylsalicylic acid at a dose of 500 mg per 1 kg of body weight for the simulation of severe toxicity. The research was conducted using injection, roentgenagiographic, histologic, morphometric and statistical techniques.
Results and Discussion. It has been established that in severe cases of acute poisoning with acetylsalicylic acid in the kidneys, there are pronounced morphofunctional signs of organ blood circulatory disorders, which manifest themselves as a significant congestive venous plethora. In response to this, the arterial section of the blood vessel is reflexively responsive to an increase in the tone of the intercellular arteries and arterioles with a decrease in their throughput, which may be a protective response to prevent haemodynamic overload of the hemomycocirculatory link and is described in the scientific literature as a reflex of Kitaev. At the same time there is a compensatory expansion of the lumen with an increase in the capacity of the arc and particle arteries. The revealed vascular reactions can be the reason for the development of functional and dystrophic changes in the structural components of the parenchyma of the organ as a morphological substrate of renal failure, which is fully consistent with modern ideas about the mechanisms of development of organ failure.
Conclusions. In the severe degree of acute poisoning with acetylsalicylic acid in rat kidneys, there are pronounced morphofunctional signs of organ blood circulation disorders, which consist in stagnant venous full blood flow, reflex increase in tone between interstitial arteries and arterioles and compensatory enlargement of the lumen of the arcuate and interstitial arteries. The revealed vascular reactions can be the reason for the development of functional and dystrophic changes in the structural components of the parenchyma of the organ as a morphological substrate of renal insufficiency.
References
Yurchenko, T.M., Hovorukha, T.P., Marchenko, L.M., Kondakov, I.I., & Riepin, M.V. (2012). Ultrastruktura i funktsionalni osoblyvosti nyrok shchuriv pry modeliuvanni toksychnoi hostroi nyrkovoi nedostatnosti [Ultra-structure and functional features of rat kidneys in the modeling of toxic acute renal failure]. Eksperementalna i klinichna medytsyna – Experimental and Clinical Medicine, 3, 49-53 [in Ukrainian].
Mowry, J.B., Spyker, D.A., Brooks, D.E., McMillan, N., & Schauben, J.L. (2014). Annual Report of the American Association of Poison Control Centers' National Poison Data System (NPDS) : 32nd Annual Report. Clin Toxicol (Phila), 53 (10), 962-1147.
Madan, R.K., & Levitt, J.A. (2014). Review of toxicity from topical salicylic acid preparations. J Am Acad Dermatol, 70 (4), 788-792.
Pearlman, B.L., & Gambhir, R. (2009). Salicylate intoxication : a clinical review. Postgrad Med, 121 (4), 162-168.
Mund, M.E., Gyo, C., Brüggmann, D., Quarcoo, D., & Groneberg, D.A. (2016). Acetylsalicylic acid as a potential pediatric health hazard: legislative aspects concerning accidental intoxications in the European Union. J Occup Med Toxicol, 11, 32.
Davis, J.E. (2007). Are one or two dangerous? Methyl salicylate exposure in toddlers. J Emerg Med. Jan, 32 (1), 63-69.
Temple, A.R. (1981). Acute and chronic effects of aspirin toxicity and their treatment Archives of Internal Medicine, 141, 364-369.
Chyka, P.A., Erdman, A.R., Christianson, G., Wax, P.M., Booze, L.L., … & Troutman, W.G. (2007). Salicylate poisoning: an evidence-based consensus guideline for out-of-hospital management. Clinical Toxicology Philadelphia, 45 (2), 95-131.
Lepeiko, Yu.B., Nevzorova, V.A., Hylyfanov, E.A., Pavlush, D.H., & Diuizen, Y.V. (2015). Yzmenenye aktyvnosty neirokynynovoi systemy v slyzystoy obolochke verkhnykh dykhatelnykh putei krys pry modelyrovanyy khronycheskoho tabakokureniya [Changes in the activity of the neurokinin system in the mucous membrane of the upper respiratory tract of rats in the simulation of chronic tobacco smoking]. Sybyrskyi nauchnyi medytsynskyi zhurnal – Siberian Scientific Medical Journal, 35 (1), 19-27 [in Russian].
Shormanov, Y.S. (2004). Sosudystaia systema pochek pry stenoze lehochnoho stovola s razlychnym urovnem kompensatsyy krovoobrashcheniya [Vascular system of the kidneys with stenosis of the pulmonary trunk with different levels of blood circulation compensation]. Biuleten eksperymentalnoy byolohyy y medytsyny – Bulletin of experimental biology and medicine, 137 (3), 332-335 [in Russian].
Esypova, Y.K., Kaufman, O.A., & Kriuchkova, T.S. (1971). Ocherky po hemodynamycheskoi perestroike sosudystoi stinky [Essays on hemodynamic reconstruction of the vascular wall]. Moskva : Medytsyna, p. 312 [in Russian].
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