DETECTION AND TREATMENT OF PATIENTS WITH FAMILIAL HYPERCHOLESTEROLEMIA

Authors

  • O. O. Yakimenko Odesa National Medical University
  • Ie. O. Maznichenko Odesa National Medical University

DOI:

https://doi.org/10.11603/2415-8798.2018.3.9412

Keywords:

familial hypercholesterolemia, hypolipidemic therapy, statins

Abstract

At present, the problem of the detection and treatment of patients with atherosclerosis is mainly due to the fact that there is no nationwide program to combat atherosclerosis, cholesterol screening and other risk factors, there is not enough adequate awareness of the population on the issues of this specialty and media support, ineffective vascular centers concerning reduction of lethality, insufficient patient adherence to the treatment, failure to reach the target levels of low density lipoprotein and inherent fear of administration the maximal doses of statins. Over the last decade, many data have been accumulated on familial hypercholesterolemia, and it is known that the prevalence of the disease has been more frequent than previously anticipated. Familial hypercholesterolemia is a hereditary disease that is associated with the early development of aggressive atherosclerosis and cardiovascular disease at young age, and is characterized by a severe course with high mortality. The paper provides an overview of the current state of epidemiology, prevention and management of patients with familial hypercholesterolemia, emphasizes the early detection of patients and screening of the family.

References

(2012). Semeynaya giperkholesterinemiya : obsledovaniye, diagnostika i lecheniye vzroslykh i detey. Klinicheskoye rukovodstvo gruppy ekspertov po semeynoy gi-perkholesterinemii Natsionalnoy lipidnoy assotsiatsii SSHA [Familial hypercholes-terolemia: examination, diagnosis and treatment of adults and children. Clinical Guide-lines of the Family Hypercholesterolemia Group of Experts at the United States National Lipid Association]. Afferentnaya i fiziko-khimicheskaya meditsina – Afferent and Physico-Chemical Medicine, 1, 3-9 [in Russian].

(2013). Sovremennyye rekomendatsii Yevropeyskogo obshchestva kardiologov i Yev-ropeyskogo obshchestva po bor'be s aterosklerozom po lecheniyu dislipidemiy [Modern recommendations of the European Society of Cardiology and the European Society for the fight against atherosclerosis for the treatment of dyslipidemia]. Ukrainskii terapevtichnyi zhurnal – Ukrainian Journal of Therapeutics, 2, 12-23 [in Russian].

Yezhov, M.V., Sergiyenko, I.V., & Ryzhkova, T.A. (2016). Rossiyskiye rekomendatsii po diagnostike i lecheniyu semeynoy giper-kholesterinemii [Russian recommendations on the diagnosis and treatment of familial hyper-cholesterolemia]. Ateroskleroz i dislipidemii – Atherosclerosis and Dyslipidemia, 4 (25), 21-29 [in Russian].

(2014). Integrated guidance on the care of familial hypercholesterolemia from the In-ternational FH Foundation. International Journal of Cardiology, 171, 309-325.

Nathan, D., Wong, D., Rosenblit, P., Greenfield, S.R. (2017). Advanced in dyslipidemia management for prevention of athero-sclerosis: PCSK9 monoclonal antibody therapy and beyond. Cardiovas. Diagn. Ther., 7 (Suppl. 1), 11-20.

Atheroscler, J. (2017). Half of century tales of familial hypercholesterolemia (FH) in Japan. Divi-sion of Clinical Lipidology, Department of Cardiology, Kanazawa University. Thromb, 24, 189-207.

Sharifi, M., Futema, M., Humphries, S.E. (2017). Genetic architecture of Familial Hy-percholesterolemia. Curr. Cardiol. Rep., 19, 19-44.

Hovingh, G.K., Davidson, M.H., Kastelein, J.J.P., & O’Connor, A.M. (2013). Diagnos-tic and treatment of familial hypercholesterolemia. Europen Heart J., 34, Issue 13, 962-971.

De Lorenzo, A., Duarte Lopes da Silva, J., James, C.E., Pereira, A.C., & Seixas Bello Moreira, A. (2018). Clinical, Anthropometric and biochemical characteristics of patients with or without genetically confirmed Familial Hypercholesterolemia. Arq. Bras. Cardiol, 110, 119-123.

Kłosiewicz-Latoszek, L., Cybulska, B., Białobrzeska-Paluszkiewicz, J., Jagielska, A., Janowska, J., Danowska, D., … & Stroniawska-Woźniak, M. (2018). Clinical manage-ment of heterozygous familial hypercholesterolemia in a Polish outpa-tient metabolic clinic : a retrospective observational study. Arch. Med. Sci., 14 (5), 962-970.

Published

2018-10-12

Issue

Section

EXCHANGE OF EXPERIENCE

How to Cite

DETECTION AND TREATMENT OF PATIENTS WITH FAMILIAL HYPERCHOLESTEROLEMIA. (2018). Bulletin of Scientific Research, 3, 146-151. https://doi.org/10.11603/2415-8798.2018.3.9412