CLINICAL IMPACT OF NT PRO-BNP IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION: DATA ANALYSIS AND OWN OBSERVATIONS
DOI:
https://doi.org/10.11603/2415-8798.2018.3.9348Keywords:
myocardial infarction, heart failure, brain natriuretic peptide, N-terminal prohormone of brain natriuretic peptide (Nt pro-BNP), survival, left ventricle remodelingAbstract
The recent data statistics shows that the heart failure is the main reason for a low quality of life in patients following myocardial infarction (MI). Ischemic heart disease is the leading cause of death in Europe and it takes up to 862 thousand (19 % of total death) lives of men and 877 thousand (20 % of total death) lives of women per year. According to ECVDS 2017 mortality rates in Ukraine are higher for women (75 %) than men (59 %). Therefore, the optimization of early diagnostics and treatment of patients with MI is the key point nowadays in our clinical practice.
The aim of the study – to diagnose the heart failure in patients with acute MI, measuring the level of Nt pro-BNP.
Materials and Methods. The analysis of the dynamics of Nt pro-BNP in 58 patients (mean age (62.7±1.07) years old) with acute MI has shown the correlation with the clinical and instrumental parameters as well as survival.
Results and Discussion. The analysis of patients survival after MI has shown the great value of using Nt pro-BNP in everyday clinical practice. The Nt pro-BNP levels were authentically higher in those individuals with acute coronary events, increasing the mortality level (r=0.297, p=0.023). We observed the correlation between NT pro-BNP and age of a patient (r=0.391, p=0.0027), smoking (r=0.322, p=0.046), heart rate in the acute stage of MI and after 3 month (r=0.433, p=0.008 and r=0.45, p=0.009), left ventricular systolic dimension (r=394, p=0.022), longitudinal systolic shortening of the left ventricle (r=-0.425, p=0.015), left ventricle ejection fraction (r=-0.352, p=0.044), left ventricular wall thickness (r=0.319, p=0.048), left ventricle mass index (r=0.361,p=0.028).
Conclusions. The Nt pro-BNP has a great value in everyday clinical practice. The higher levels of Nt pro-BNP in patients with MI predict a higher risk for the development of the heart failure. Taking this into consideration, it is very important to optimize the treatment of MI on early stages, in a due to improve the cardiac function.
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