PECULIARITIES OF THE ARTERIAL HYPERTENSION IN WOMEN OF POSTMENOPAUSAL PERIOD WITH DISTURBANCES OF BONE MINERAL DENSITY AND DYSLIPIDEMIA
DOI:
https://doi.org/10.11603/2415-8798.2018.3.9252Keywords:
arterial hypertension, postmenopause, bone mineral density, dyslipidemiaAbstract
The topicality of the problem is due to the detection of the association of lipid and mineral metabolism disturbances with an increased risk of mortality in patients with cardiovascular diseases.
The aim of the study – to investigate the features of mineral density of bone tissue, lipid spectrum, lipid peroxidation and antioxidant activity of female patients with essential arterial hypertension in the postmenopausal period.
Materials and Methods. 193 female patients with the second stage of essential arterial hypertension aged 45 to 62 years were examined. The first (main) group included 137 female patients (70.9 %) in the postmenopausal period, and the second group (comparison group) included 56 (29.1 %) female patients with preserved menstrual function. The control group consisted of 30 healthy women, of whom 19 women (63.3 %) were in the postmenopausal period and 11 (36.7 %) women were in reproductive period. Two-photon X-ray densitometry, lipid profile and lipoperoxidation indexes were performed for all patients.
Results and Discussion. Bone mineral density values are significantly lower in postmenopausal female patients with essential arterial hypertension in comparison with the control group of women without hypertension, respectively, in 11.3 % (p<0.05) and 14.4 % (p<0.05), which may be due to the negative influence of arterial hypertension on bone tissue. Correlation between the atherogenicity factor and the duration of menopause (r = 0.40, p<0.01) and the inverse correlation between the atherogenicity factor and the age of menopause onset (r = -0.27 , p<0.01) in female patients with hypertension in the postmenopausal period were found. Higher rates of lipoperoxidation processes and reducing of antioxidant enzymes activity were revealed with an increase of the duration of menopause.
Conclusions. The prescription of arterial hypertension as well as the fact of menopause onset and the duration of the postmenopausal period are the independent predictors of the progression of osteoporosis in female patients with essential arterial hypertension. The earlier menopause occurs in women with hypertension, the faster the progression of atherogenicity of plasma lipids, with significantly higher lipoperoxidation and antioxidant deficiency.
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