INDICES OF EXCHANGE OF IRON DEPENDING ON THE FUNCTIONAL CLASS OF CHRONIC HEART FAILURE AMONG PATIENTS WITH COMORBID IRON DEFICIENCY
DOI:
https://doi.org/10.11603/1681-2786.2018.3.9765Keywords:
chronic heart failure, latent iron deficiency, iron deficiency anemia, indices of exchange of ironAbstract
Purpose: to analyze the significance of red blood cells and ferrokinetics, depending on the functional class (FC) of CHF with reduced left ventricular ejection fraction in patients with comorbid ID.
Material and methods. There was conducted the analysis of hematological parameters and parameters of ferrokinetics of 122 patients with CHF hypertensive in combination with ischemic etiology with a reduced fraction of left ventricular ejection and accompanying ID depending on the size of the functional class (FC) of CHF.
Results. It was revealed that among patients with concomitant latent ID and iron deficiency anemia, with increasing FC of CHF, the parameters of ferrokinetics are decreasing.
At the group of patients with CHF with a reduced fraction of left ventricular ejection and concomitant IDA among patients of III FC, the mean values of Hb, Hct and Rbc were significantly lower than the average values of patients with II FC in the same group. Among the indicators of ferrokinetics were significantly lower average levels of ferritin, transferrin saturation with iron (TSI) and a significantly higher level of the total iron binding capacity of the blood serum (IBCS). In the group of patients with CHF with a reduced fraction of left ventricular ejection and latent ID among patients of III FC, a significant difference was found only in the value of TSI.
Conclusions. The most significant among the hematological and ferrokinetic indicators, for the physical activity of patients with CHF and IDA is Hb, Hct, Rbc, ferritin and TSI, which low values associated with higher FC. A reduction in the TSI indicates a deterioration in the functional status of patients with CHF with a reduced fraction of left ventricular ejection and accompanying ID, both with and without anemia.
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