CLINICAL AND PHARMACOLOGICAL ANALYSIS OF MEDICATION PROVISION IN PATIENTS WITH ACUTE CEREBROVASCULAR DISORDERS
DOI:
https://doi.org/10.11603/1681-2786.2026.2.16421Keywords:
acute cerebrovascular disorders; pharmacotherapy; clinical and pharmacological analysis; Medical Guarantees Program; National List of Essential Medicines.Abstract
Objective. To conduct a clinical and pharmacological analysis of pharmacotherapy in patients with acute cere- brovascular disorders and to evaluate the rationality and effectiveness of the implementation of the state pharma- ceutical provision model in a hospital setting. Materials and Methods. A single-center retrospective analytical study was conducted in a specialized health- care institution. Medical records of 72 patients with acute cerebrovascular disorders were analyzed. A clinical and pharmacological approach based on international nonproprietary names (INN) was applied to evaluate prescribed pharmacotherapy. The assessment included adherence to current clinical protocols, European Stroke Organisation (ESO) and World Stroke Organization (WSO) guidelines, the National List of Essential Medicines of Ukraine, and the level of reimbursement coverage under the Medical Guarantees Program. Results. Ischemic stroke was the predominant diagnosis (75%), while hemorrhagic stroke accounted for 25% of cases. Pharmacotherapy demonstrated a multimodal structure and included systemic thrombolysis, antithrom- botic therapy, antihypertensive agents, infusion therapy, osmotic agents, and neurometabolic drugs. Overall, a high level of compliance with clinical protocols was observed. However, full adherence to the National List of Essential Medicines was not consistently achieved due to the variable regulatory status of certain medicinal products and heterogeneous reimbursement coverage within the Medical Guarantees Program. The findings demonstrate a gen- erally high level of implementation of evidence-based pharmacotherapy, while also revealing insufficient regulatory standardization of treatment regimens. Conclusions. The state model of pharmaceutical provision for patients with acute cerebrovascular disorders is clinically justified and ensures access to essential medicines as well as continuity of emergency care. Further improvement should focus on strengthening the standardization of prescribing practices and integrating health technology assessment (HTA) methodologies to enhance both clinical outcomes and pharmacoeconomic efficiency of therapy.
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