USE OF Xpert MTB/RIF IN MOLECULAR DIAGNOSTICS OF PLEURAL TB EMPYEMA
DOI:
https://doi.org/10.11603/mie.1996-1960.2019.4.11019Keywords:
tuberculosis, molecular diagnosis (Xpert MTB/RIF), tuberculosis empyema, videothorcoscopy (VTS), video-assisted surgical resection (VATS), open pleurectomy with decortication of the lungsAbstract
Background. The first of effective analysis of the test diagnosis of patients with pleural TB empyema from the use of Xpert MTB/RIF examination in Videothoroscopic (VTS) studies of the chest organs is presented.
Materials and methods. Results. The thoroscopic features of developpment, localization in diagnostics of pleural TB are analyzed into depending on the sex, age, beginning, course and prevalence of suppuration. The feature of Xpert MTB/ RIF Express in early diagnosis of TB empyema pleura and Minimally invasive surgical treatment (VTS, VATS) of patients is shown.
Conclusions. In patients with tuberculosis empyema of the pleura, only 51.2 % of pleural empyema was diagnosed in a timely manner, that is, at the stage of a possible minimally invasive surgical treatment. Analysis of the diagnostic value of standard methods for the diagnosis of tuberculosis suppuration in patients with tuberculosis showed that the timely detection of such a complication is significant difficulty. In 48.7 % of patients, tuberculosis empyema was diagnosed at a late stage of the purulent process, which confirms the need for widespread use in the diagnosis of Xpert MTB/RIF testing, which provides higher sensitivity than microscopy.
References
Shipulin P. P. (2010). Primenemnija raniy dekortikacii legkogo v lechenii ostroy empiema pleuri I nagnoivshegosja svernutogo gemotoraxa. КИт^ш khirurgia (Clinical Surgery), 10, 29-31. [In Ukraine].
Opanasenko M. S., Shalagay S. M., Klimec E. V. (2017). Endoskopichni metodi likuvanja pidhostrich I chronichnich zapalnich zachvoruvan pleuri. Кlinichna khirurgia (Clinical Surgery), 1, 39-42. [In Ukraine].
Duzhij, I. D. (Ed) (2016). Pitanja epidemyologii empiemy pleuri. Ukrainskiy Pulmonologichniy Zhurnal (Ukrainian Pulmonogy Journal), 3, 60-3. [In Ukraine].
Opanasenko, M. S., (Ed) (2017). Obgruntovanja efektivnosti vikoristanja videoasistovanogo dostupu v khirurgii zapalnich procesiv pleuri. Кlinichna khirurgia (Clinical Surgery), 7, 37-40 [In Ukraine].
Williamson, D. A. et al. (2012). An evaluation of the Xpert MTB/RIF assay and detection of false-positive rifampicin resistance in Mycobacterium tuberculosis. Diagnostic Microbiology and Infectious Diseases, 74, 207-9. DOI: https://doi.org/10.1016/j.diagmicrobio.2012.06.013
Van Deun A., et al. (2013). Rifampicin drug resistance tests for tuberculosis: challenging the gold standard. Journal of Clinical Microbiology, 51, 2633-40. DOI: https://doi.org/10.1128/JCM.00553-13
Theron, G et al. (2013). Feasibility, Accuracy, and Clinical Effect of Point-of-care Xpert MTB/RIF Testing for Tuberculosis in Primary-care Settings in Africa: a Multicentre, Randomised, Controlled Trial. Lancet.
Subotic, D., (Ed) (2016). Surgery and pleura-pulmonary tuberculosis: a scientific literature review. J.Thorac. Dis., 8 (7), E474-85.
Gx Alert open source software, 2014 (http://www.gxalert.com по состоянию на 11.12.2013 года).
Xpert SMS automated reporting of GeneXpert results. Karachi, Interactive Research and Development, 2014. URL: http://irdresearch.org/xpert-smsautomated-reporting-of-genexpert-results.
Rachow, A. et al. (2012). Increased and Expedited Case Detection by Xpert MTB/RIF Assay in Childhood Tuberculosis: a Prospective Cohort Study. Clinical Infectious Diseases, 54, 1388-96. DOI: https://doi.org/10.1093/cid/cis190
Guidance on ethics of tuberculosis prevention, care and control. Geneva, World Health Organization, 2010. URL: http://whqlibdoc.who.int/publications/ 2010/9789241500531_eng.pdf.
Downloads
Published
How to Cite
Issue
Section
License
Journal Medical Informatics and Engineering allows the author(s) to hold the copyright without registration
The majority of Medical Informatics and Engineering Open Access journals publish open access articles under the terms of the Creative Commons Attribution (CC BY) License which permits use, distribution and reproduction in any medium, provided the original work is properly cited. The remaining journals offer a choice of licenses.
This journal is available through Creative Commons (CC) License CC-BY 4.0
