Low efficacy of simvastatin in treatment of nonalcoholic fatty liver disease in rats
We determined the possibility of simvastatin in non-alcoholic fatty liver disease in rats. The animals were kept for 2 months at high-fatty diet with additional input homocysteine thiolactone. Then, the animals were divided into groups according to the doses (20 or 40 mg/kg body weight) and duration of treatment (14 or 28 days). At the end of experiment there was determined the concentration of homocysteine, serum biochemical parameters, intensity of oxidative stress and antioxidant defense, and the degree of hepatic fibrogenesis and steatohenesis. It was shown that simvastatin did not improve the health of rats.
Pentiuk, O. O., Lutsiuk, M. B., Andrushko, I. I., Postovitenko, K. P. (2003). Metabolizm homotsysteinu ta yoho rol v patolohii. Ukr. biokhim. Zhurn, 75 (1), & 5–17.
Lutsiuk, M. B., Zaichko, N. V., & Hryhorieva, H. S. (2013). Syndrom hiperhomotsysteinemii: prychyny vynyknennia, sposoby profilaktyky ta likuvannia. Ratsyonalnaia farmakoterapyia, 29 (4), 55–60.
Abraham, J. M., & Cho, L. (2010). The homocysteine hypothesis: still relevant to the prevention and treatment of cardiovascular disease. Cleve Clin. J. Med, 77(12), 911–918.
Brustolin, S., & Giugliani, R. (2010). Genetics of homocysteine metabolism and associated disorders. Braz. J. Med. Biol. Res, 43, 1–7.
Ansari, R., Mahta, A., Mallack, E., Luo, J. J. (2014). Hyperhomocysteinemia and Neurologic Disorders: a Review. J. Clin. Neurol, 10 (4), 281–288.
Faloon W. AS WE SEE IT. Newly Identified Risks Of Excess Homocysteine. (2015). Life Extension Magazine.
Soboleva, E. V., & Lebedev, P. A. (2007). Homotsysteynemyia v patoheneze yshemycheskoi bolezny serdtsa. Pleiotropnыe эffektы statynov. Vesnyk SamHU, 2, 242–255.
Nekrut, D. O., Yakovlieva, O. O., & Lutsiuk, M. B. (2016) Pat. 109085 Ukraina, MPK G09B 23/28 (2006.01), G01N 33/50 (2006.01). Eksperymentalna model nealkoholnoi zhyrovoi khvoroby pechinky u shchuriv. u 201601482, Biul. 15.
Ostrovskyi, Yu. M. (1979). Eksperymentalnaia vytamynolohyia. sprav. Rukovodstvo. Mynsk, Nauka y tekhnyka, 552.
Copyright (c) 2016 Medical and Clinical Chemistry
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.