SELECTION OF EXCIPIENTS FOR OBTAINING CAPSULATION MASS WITH DRY EXTRACT OF MARIGOLDS
DOI:
https://doi.org/10.11603/mcch.2410-681X.2023.i4.14382Keywords:
mass for encapsulation, dry extract, marigolds, excipients, capsulesAbstract
Introduction. Plant raw materials are widely used to prevent and treat many diseases. An in-depth study of the flowers, leaves and herbs of Tagetes lucida and the creation of medicines based on them is an interest. It is known that, in addition to active pharmaceutical ingredients (API), various groups of auxiliary substances (excipients) are included in the composition of ready-made medicinal products. Increasing the accuracy of the API dosage, improving absorption and solubility of the drug, improving stability (extend the shelf life) and promotion better patient tolerance and perception of the drug, including its appearance and taste is a main purpose of adding an excipient to the drug composition.
The aim of study – to select auxiliary substances for creating capsules based on the dry extract of the marigold herb Tagetes lucida.
Research Methods. The influence of 9 excipients on the technological properties of the masses for encapsulation based on the dry extract of marigolds and the rationale for choosing the best excipients in the development of the encapsulated drug using the method of mathematical planning of the experiment were studied.
Results and Discussion. At the first stage of the experiment, the morphometric and pharmacotechnological parameters of the dry extract of the marigold herb Tagetes lucida were studied. In our works, we considered the selection of excipient leaders according to their properties and functional purpose for obtaining powder mass with the dry extract of the marigold herb Tagetes lucida. In addition, the main technological aspects were covered, which consisted in choosing the best combinations of excipients and in the method of introducing the dry extract into the powder mass.
The study and selection of excipients in the development of a drug based on dry extract of marigolds in the form of capsules were carried out.
Conclusions. It was found that to obtain a mass for encapsulation with the necessary pharmaco-technological indicators, it is advisable to use the following combination of excipients: Lycatab PGS, compri Zucker and Prosolv.
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