INVESTIGATION OF THE OPTIMAL COMPOSITION OF CAPSULE MASS WITH ESSENTIAL OIL OF THYME ORDINARY IN THE DEVELOPMENT OF SOLID CAPSULES

Abstract

Introduction. Pharmaceutical development of mucolytic drug based on thick extract of creeping thyme (CT) and essential oil of thyme ordinary (TO) in the form of solid capsules included, first of all, the technology of obtaining liquid and thick extracts of CT. The latter, obtained by technology, which allowed to preserve and reproduce biologically active substances (BAS) of CT grass. In previous works, we considered the selection of excipient leaders according to their properties and functional purpose for obtaining powder mass with TO essential oil. In addition, the main technological aspects were highlighted, which consisted in choosing the best combinations of excipients and in the method of introducing TO essential oil into the powder mass. It was also necessary to study the influence of quantitative factors on the properties of the resulting powder mass, which will allow you to choose the appropriate amount of excipients, study their interaction and offer the optimal composition of the capsule mass with TO essential oil with satisfactory pharmaco-technological indicators for filling solid gelatin capsules.

The aim of the study – selection of quantities of excipients and the study of their impact on the quality of the resulting capsule mass on the basis of TO essential oil in the development of solid capsules.

Research Мethods. Essential oil of thyme ordinary, excipients (neusillin UFL2 (Fuji Chemical Industry, Japan), brine SMHD 90 (JRS Pharma, Germany), calcium dihydrophosphate (JRS Pharma, Germany)), regression analysis.

Results and Discussion. The study of the influence of quantitative factors on the properties of capsule mass was carried out by regression analysis, using a symmetrical compositional rotatable uniform-plan of the second order. As a result, 14 experiment experiments were implemented and 6 additional ones were implemented to establish the experimenter's error. For the obtained powder masses with TO essential oil, the main pharmaco-technological indicators of the capsule mass were determined, the relationship between them in the form of regression equations was shown, which led to the canonical appearance and, on the basis of transformed models, built equal-yield lines. Taking into account the results of their placement, the optimal composition of the capsule mass based on TO essential oil was proposed.

Conclusions. The use of regression analysis made it possible to select the optimal amounts of selected excipients, as well as to study their impact on the quality of the capsule mass obtained on the basis of TO essential oil and offer its optimal composition when creating solid capsules.