DISORDERS OF CONNECTIVE TISSUE METABOLISM AND THE STATE OF THE REDOX-SYSTEM IN PREGNANT WOMEN WITH UNDIFFERENTIATED CONNECTIVE TISSUE DYSPLASIA SYNDROME IN PREMATURE BIRTH

Authors

  • V. Yu. Dobrianska I. HORBACHEVSKY TERNOPIL NATIONAL MEDICAL UNIVERSITY

DOI:

https://doi.org/10.11603/mcch.2410-681X.2021.i2.12241

Keywords:

undifferentiated connective tissue dysplasia, premature birth, lipid peroxidation, oxyproline, transforming growth factor

Abstract

Introduction. Undifferentiated connective tissue dysplasia syndrome in pregnant women is a common cause of perinatal complications, including premature birth.

The aim of the study – to learn the dynamics of connective tissue metabolism, the state of lipid peroxidation and antioxidant system and to develop additional criteria for predicting and diagnosing pregnancy complications, premature birth in women with undifferentiated connective tissue dysplasia.

Research Methods. 38 pregnant women with UCTD in different stages of gestation (I–III trimesters) and 24 healthy pregnant women of the control group were examined. In addition to general clinical and obstetric examinations, questionnaires were conducted to identify phenotypic markers of connective tissue dysplasia, determine the activity of lipid peroxidation and antioxidant defense systems and the state of connective tissue metabolism by blood levels of transforming growth factor β1 and oxyproline.

Results and Discussion. In pregnant women the frequency of signs of UCTD was determined in 29.3 %, the frequency of premature birth was 11.1 % in the experimental group against 5.2 % in the control. At the same time in pregnant women with signs of UCTD already in the first trimester of gestation there was a significantly higher activity of oxidative processes (the level of MDA increased by 66.5 %) against the background of reduced enzymatic (11–15 %) and non-enzymatic (30 %) antioxidant protection, and catabolic processes prevailed in the connective tissue, as evidenced by the increase in daily excretion of oxyproline. In the II-III trimesters of gestation, these changes increased significantly, which became a trigger for premature birth.

Conclusions. In pregnant women with UCTD syndrome there is a pronounced progressive activation of lipid peroxidation and antioxidant system insufficient, which is a threat of perinatal complications. When critical levels are reached against the background of the predominance of catabolic processes in connective tissue becomes a trigger for premature birth.

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Published

2021-08-04

How to Cite

Dobrianska, V. Y. (2021). DISORDERS OF CONNECTIVE TISSUE METABOLISM AND THE STATE OF THE REDOX-SYSTEM IN PREGNANT WOMEN WITH UNDIFFERENTIATED CONNECTIVE TISSUE DYSPLASIA SYNDROME IN PREMATURE BIRTH. Medical and Clinical Chemistry, (2), 63–69. https://doi.org/10.11603/mcch.2410-681X.2021.i2.12241

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Section

ORIGINAL INVESTIGATIONS