Morphological features of the prostate gland under conditions of iodine deficiency and iodine deficiency combined with the goitrogenic substances during postnatal ontogenesis
DOI:
https://doi.org/10.11603/bmbr.2706-6290.2026.2.16371Keywords:
laboratory animals, experiment, prostate, morphology, morphometry, age, ontogenesisAbstract
Abstract. According to data from the World Health Organization, pathological conditions caused by iodine deficiency rank third place of the most common non-infectious human diseases. The aim of the study was to determine the morphofunctional changes in the prostate gland over time at 60 and 90 days of iodine deficiency combined with the consumption of goitrogenic substances during postnatal ontogenesis. The experiment was conducted on 78 white inbred male rats of both prepubertal and pubertal ages. Eleven animals from each age group constituted Group 1 (control), while 14 animals were included in experimental groups 2 and 3 with simulated iodine deficiency. Experimental Groups 4 and 5 experimental groups consisted of animals from both age groups in which combined iodine deficiency with goitrogen consumption was simulated. Material for light and electron microscopy were collected on days 60 and 90 of the experiment. From a morphological view, the structural changes observed in the prostate gland involve several levels. First, due to reduced thyroid stimulation, changes in the metabolic activity of the epithelial cells of the gland’s acini and ducts were noted. Second, endocrine imbalance altered the ratio of epithelial to stromal components. Third, since the prostate gland is sensitive to the interaction of androgens, estrogens, thyroid hormones, and pro-inflammatory mediators, the combined effect of iodine deficiency and goitrogenic agents manifested as inflammatory and dystrophic changes, specifically alterations in epithelial cell height, acinar lumen width, the stroma-to-parenchyma ratio, the presence of edema, and cellular infiltration. Thus, iodine deficiency and goitrogenic agents can alter thyroid homeostasis, and the thyroid axis is associated with the function and pathological conditions of the prostate gland. Thus, tth key components of thyroid signaling are detected in the prostate gland, indicating a possible direct effect of thyroid hormones on this organ. Edematous changes in the epithelium of the terminal secretory units result from ischemia caused by edematous processes in the walls of blood vessels and connective tissue elements of the prostate.
Отримано: 19.02.2026 | Переглянуто: 6.04.2026 | Прийнято: 1.05.2026
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