Pancreatic exocrine insufficiency impact on the course of osteoarthritis in comorbidity
DOI:
https://doi.org/10.61751/bmbr/1.2024.08Keywords:
joint syndrome, functional insufficiency of the pancreas, gastroenterological diseases, type 2 diabetes mellitusAbstract
The relationship between chronic diseases and osteoarthritis is a common phenomenon, especially among the
elderly. Patients with osteoarthritis require an integrated approach that includes the collaboration of various medical
specialists, such as general practitioners, rheumatologists, orthopaedic surgeons, gastroenterologists and traumatologists.
The study aims to investigate the impact of diseases associated with exocrine pancreatic insufficiency on the course
of primary osteoarthritis in comorbidity. A total of 304 patients with primary osteoarthritis and exocrine pancreatic
insufficiency were analysed. All patients were divided into five groups depending on the type of concomitant pathology.
The study determined that in the group of patients with primary osteoarthritis, a statistically significant improvement in
the course of the disease according to various indicators, such as the radiological stage of osteoarthritis, functional joint
failure, Lequesne index, and NSAID index, compared with those in the groups with other comorbidities, was present (p<0.05).
This confirms the significant impact of the studied comorbidities on the course of primary osteoarthritis. The post-hoc
analysis determined the ranking of the impact of comorbidities accompanied by exocrine pancreatic insufficiency on the
clinical course of primary osteoarthritis by various indicators, such as the radiological stage of osteoarthritis, functional
joint failure, Lequesne index, and the index of non-steroidal anti-inflammatory drugs. Ranking results: type 2 diabetes
mellitus > chronic pancreatitis > hepatobiliary diseases > gastro-duodenal diseases (p<0.05). The study highlighted a
mild exocrine insufficiency of the pancreas according to faecal α-elastase in the group of patients with isolated primary
osteoarthritis. The study also established the ranking of the impact of pathologies accompanied by exocrine pancreatic
insufficiency on the course of primary osteoarthritis by the level of faecal α-elastase: chronic pancreatitis < type 2 diabetes
mellitus < hepatobiliary diseases < gastro-duodenal diseases (p<0.05). The results can be used in the clinical practice of
doctors of various specialities: general practitioners, rheumatologists, gastroenterologists
Received: 16.10.2023 | Revised: 30.01.2024 | Accepted: 27.02.2024
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