The role of lipid peroxidation and antioxidant protection for development pathogenesis of experimental bronchial asthma and adrenaline myocardial damage
DOI:
https://doi.org/10.11603/mcch.2410-681X.2016.v0.i2.6673Keywords:
malondialdehyde, diene conjugates, superoxide dismutase, catalase, glutathione reductase.Abstract
The paper examined the role of lipid peroxidation (LP) and antioxidant protection in the miocardium of guinea pigs in experimental asthma (EA) in combination with adrenaline myocardial damage (AMD). Analyses were performed on the 1st, 4th, 18th and 25th day. The results showed that at all stages of the development ofEAwithAMD increased content of lipid peroxidation products (diene conjugates and malondialdehyde), while at the same time on the 1st and 4th day increases the activity of superoxide dismutase, catalase and glutathione reductase in the miocardium, followed by reduction in their on the 18th and 25th day.References
Reheda, M. S. (2012). Bronkhial'na astma. Monohrafiya. L'vov. 5,141.
Reheda, M. S. (2009). Alerhichni zakhvoryuvannya leheniv. Monohrafiya. L'vov. 168–324.
Kovalenko, V. M. (2001). Miokardyt. suchasni aspekty patohenezu ta diahnostyky . Ukr. revmat. Zhurn. 1, 18–22.
Susla, O. B. (2004). Vikovi zminy metabolizmu v sertsevomu m’yazi shchuriv u dynamitsi rozvytku adrenalinovoyi miokardiodystrofiyi. Med. Khimiya.6 (1), 41–47.
Babych, V. Y. (1979). Modyfykatsyya metoda eksperymental'noy modely bronkhyal'noy astmy u morskykh svynok. Problemy patolohyy v eksperymente y klynyke. L'vov, 3, 159.
Markova, O. O. (1998). Miokardiodystrofiya i reaktyvnist' orhanizmu.Ternopil'. Ukrmedknyha, 152.
Havrylov, V. B., & Myshkorudnaya, M. Y. (1989). Spektrofotometrycheskoe opredelenye soderzhannya hydroperekysey lypydov v plazme. Laboratornaya dyahnostyka yshemychnoy bolezny serdtsa. K. Zdorov’ya, 170–171.
Korobeynykov, E. N. (1989). Modyfykatsyya opredelenyya produktov POL v reaktsyy s tyobarbyturovoy kyslotoy . Lab. Delo.7, 8–10.
Fried, R. (1975). Enzymatic and non-enzymatic assay of superoxide ifilii .Biochemie.57(5), 657–660.
Holmes, R., &MastersC. (1970). Epigenetic interconversions of the multiple forms of mouse liver catalase. FEBS Lett.11(1), 45–48.
Moyn, V. M. (1986). Prostoy y spetsyfycheskyy metod opredelenyya aktyvnosty hlatatyonreduktazy v эrytrotsytakh. Lab. Delo.12, 724–727.
Etyka likarya ta prava lyudyny: polozhennya pro vykorystannya tvaryn u biomedychnykh doslidakh. (2003). Eksperym. ta klinich. fiziolohiya ta biokhimiya. 22(2), 108–109.
