TY - JOUR AU - Kamut, N. V. PY - 2019/01/31 Y2 - 2024/03/29 TI - PECULIARITIES OF THERAPEUTIC AND PROPHYLACTIC MEASURES IN CHILDREN OF EARLY AGE WITH PHOSPHORUS AND CALCIUM METABOLISM DISORDERS JF - Medical and Clinical Chemistry JA - MCCh VL - 0 IS - 4 SE - ORIGINAL INVESTIGATIONS DO - 10.11603/mcch.2410-681X.2018.v0.i4.9783 UR - https://ojs.tdmu.edu.ua/index.php/MCC/article/view/9783 SP - 17-23 AB - <p><strong>Introduction.</strong> Vitamin D is a substrate essential for the human body that plays a key role in the metabolism of calcium and phosphorus and accordingly is important for the development of a child.</p><p><strong>The aim of the study – </strong>to research the peculiarities of phosphorous and calcium homeostasis and to supply the children of early age born with a high body mass with vitamin D.</p><p><strong>Materials</strong> <strong>and</strong> <strong>Methods. </strong>The study included 82 children aged 3 to 6 months, with birth weight over 2.500 g and gestational age 37 weeks or more.</p><p>When a disruption of phosphorous and calcium homeostasis and the lack of 25–OH vitamin D3 was detected, in order to eliminate the main symptoms of a disease of the bone, nervous and other systems and normalization of phosphorous and calcium metabolism indicators, a correction was made with vitamin D<sub>3</sub> preparations according to protocol No. 9 of the Ministry of Health of Ukraine dated January 10. 2005.</p><p><strong>Results and Discussion. </strong>In order to evaluate the availability of 25(OH)D3 in children with vitamin D deficiency rickets, a 25(OH)D serum concentration was determined as a biochemical marker of bone remodeling.</p><p>Between the indicators of calcium (serum) and the level of 25-OH vitamin D3 after treatment there is a reliable, direct, moderate correlation (R = 0.560; p = 0.0126) in boys only. Between the indicators of alkaline phosphatase (blood serum) and the level of 25-OH vitamin D3 after treatment, there is a reliable, reverse, strong relationship (R = -0.555; p&lt;0.001). That is, with a higher level of alkaline phosphatase after treatment, there is a tendency towards a decrease in the level of 25-OH vitamin D3.</p><p><strong>Conclusions: 1. </strong>Children born with a high body mass over 4.000 g have vitamin D3 deficiency compared to children born with normal body mass.</p><p>2. Weight at birth and at the time of examination correlate with the level of vitamin D3 and is a risk factor of vitamin D3 deficiency (negative correlation).</p><p>3. Correction of vitamin D3 deficiency results in positive dynamics.</p> ER -