TY - JOUR AU - Korda, M. M. AU - Dumukhalska, Ye. B. AU - Yaroshenko, T. Ya. PY - 2018/11/08 Y2 - 2024/03/29 TI - THE EFFECT OF PEPTIDES ON THE STATE OF IMMUNE SYSTEM OF THE BODY AND CONTENT OF PROTEIN FRACTIONS IN BLOOD OF RATS AFFLICTED BY SALTS OF HEAVY METALS AND ROUNDUP JF - Medical and Clinical Chemistry JA - MCCh VL - 0 IS - 3 SE - ORIGINAL INVESTIGATIONS DO - 10.11603/mcch.2410-681X.2018.v0.i3.9568 UR - https://ojs.tdmu.edu.ua/index.php/MCC/article/view/9568 SP - 70-75 AB - <p><strong><em>Introduction</em></strong><strong>.</strong><em> Lead is a protoplasmic poison and has detrimental effects on the nervous, cardiovascular system and blood as all heavy metals. It violates enzymatic reactions, depress the immunobiological resistance of the body. Lead affects humoral immune response, that is impairment of antibody production, inhibits the production of M, E and A immunoglobulins classes and increases respiratory diseases frequency in people affected by Plumbum compounds.</em></p><p><strong><em>The aim of the study</em></strong><em>–</em><em> to reseach the effect of cystile-histidyl-tyrosyl-histidil-isoleucine </em><em>peptide </em><em>on the immune system state and content of protein fractions in </em><em>blood serum in </em><em>all ages rats</em><em> with chronic toxicosis, heavy metals and glyphosate</em><em>.</em></p><p><strong><em>Research Methods.</em></strong><em>Experiments were carried out </em><em>o</em><em>n laboratory nonlinear white male rats of three age groups: puberty, </em><em>mature</em><em> and old animals, which were injected intra</em><em>gastrica</em><em>lly for 30 days with </em><em>Plumbum</em><em> acetate, </em><em>C</em><em>uprum sulfate, glyphosate (in the form of a herbicide</em><em> roundup</em><em>). For the purpose of correction for 21 days 6 hours after the administration of the toxicants for 10 days, the cystile-hystidyl-tyrosyl-histidil-isoleucine peptide was injected. The state of the immune system was assessed by the level of A, M, G immunoglobulins</em><em> and circulating immune complexes</em><em> in the blood serum of rats.</em></p><p><strong><em>Results and Discussion.</em></strong><em>It </em><em>was</em><em> established that in </em><em>intact rats when combined</em><em> action of </em><em>Plumbum</em><em> acetate, </em><em>C</em><em>uprum sulfate, glyphosate (in the form of a herbicide</em><em> roundup</em><em>), the concentration of circulating immune complexes (CIC) and immunoglobulins in the blood serum of animals</em><em> increased with age</em><em>. The introduction of the peptide leads to partial restoration of the ratio of protein fractions in blood serum of rats and the content of immunoglobulins.</em></p><p><strong><em>Conclusion</em></strong><em>. T</em><em>he use of the peptide as a correction factor partially normalizes the state of the immune system and the ratio of protein fractions in blood serum of rats</em><em> with toxicosiscause</em><em>d by Pl</em><em>u</em><em>m</em><em>b</em><em>um acetate, </em><em>C</em><em>uprum sulfate and the round</em><em>up</em><em>.</em></p> ER -