TY - JOUR AU - Sklyarova, Yu. O. AU - Denysenko, N. V. AU - Ilkiv, I. I. AU - Fomenko, I. S. PY - 2016/11/21 Y2 - 2024/03/28 TI - Roleofgasotransmitters: nitrogen oxide and hydrogen sulfide in smool intestine of rats under cyclooxygenase and lipoxygenase inhibition JF - Medical and Clinical Chemistry JA - MCCh VL - 0 IS - 3 SE - ORIGINAL INVESTIGATIONS DO - 10.11603/mcch.2410-681X.2016.v0.i3.6945 UR - https://ojs.tdmu.edu.ua/index.php/MCC/article/view/6945 SP - 54-58 AB - <p>Inexperimentstherewerecomparedthecyclooxygenaseinhibitionbyindomethacinanddualcycloocygenaseandlipoxygenaseblockageby 4-thiazolidinonederivatives, capabletoreleasehydrogensulfidein small intestine. Itwasshownthatindomethacinwasaccompaniedbytheformationoflesions in the distal part ofsmall intestine, significantactivationofinducibleNO-synthase, thedecreaseofH<sub>2</sub>Sproduction, riseinmalonicdialdehydeconcentrationand activity of myeloperoxidase. Theadministrationof5-(3,5-di-tert-butyl-4-hydroxybenzylidene)-4-thyoxo-thiazolidine-2-onand 2-[(4-chlor-phenyl-carbamoyl)-methyl]-3-(3,5-di-tert-butyl-4-hydroxyphenyl)-acrylicaciddidn’tdemonstrateanulcerogenicactioninsmallintestine, thatwasprobablycausedbythereleaseofH<sub>2</sub>S from these compounds.</p> ER -