TY - JOUR AU - Malinovska, L. I. AU - Zahrychuk, O. H. AU - Krynytska, I. Ya. AU - Romanyuk, L. B. PY - 2023/02/28 Y2 - 2024/03/29 TI - INFLUENCE OF GLYCEMIA LEVELS IN PATIENTS WITH DIABETES ON THE STATUS OF THE MICROBIOME OF DIFFERENT BIOTOPES JF - Medical and Clinical Chemistry JA - MCCh VL - IS - 4 SE - REVIEWS DO - 10.11603/mcch.2410-681X.2022.i4.13582 UR - https://ojs.tdmu.edu.ua/index.php/MCC/article/view/13582 SP - 107-112 AB - <p><strong>Introduction.</strong> The incidence of diabetes mellitus, which is steadily increasing in the human population, and the complications that occur in such patients, caused by representatives of the autochthonous microflora, prompt the study of the reasons that contribute to such processes, in particular, the influence of glycated hemoglobin levels and changes in the pathogenic properties of microorganisms in patients with diabetes.</p><p><strong>The aim of the study</strong> – to investigate literature data on changes in the structure and properties of the microbiome of certain biotopes, patients with diabetes, and to find out the influence of glycated hemoglobin levels on the properties of representatives of the microflora.</p><p><strong>Research Methods.</strong> To carry out this review, we analyzed articles published in scientific journals. For the search, we used databases of leading foreign publications. Those articles containing information about the course of diabetes and the state of the microbiome of certain areas were chosen as the selection criteria.</p><p><strong>Results and Discussion.</strong> The review presents and analyzes the results of domestic and foreign research, with references to primary sources, on changes in the structure and certain properties of microorganisms – representatives of the autochthonous microflora of the oral cavity, stomach, intestines, conjunctiva, the frequency of detection of pathogenic and conditionally pathogenic microorganisms in the above biotopes. Their impact on glucose metabolism, the impact of glycemic levels on biodiversity and virulence properties of microbiota, in particular S. aureus, Helicobacter pylori, Staphylococcus epidermidis and others, changes in the ratio of aerobic and anaerobic intestinal microbiota in patients with diabetes and when it is combined with other nosological forms and in experimental conditions.</p><p><strong>Conclusions. </strong>Summarizing the results of the studied literature data, it can be stated that the level of glycated hemoglobin directly or indirectly affects the frequency of bacterial complications in patients with DM, namely by increasing the virulence properties of representatives of the normal flora of different biotopes, increasing the colonization of specific areas of the mucous membranes or skin by a certain microbe, and disrupting the relationship between different representatives of a separate biotope.</p> ER -