@article{Tatarchuk_Shulgay_Hnatjuk_2019, title={FEATURES OF ENERGY SUPPLYING OF THE MUSCLE OF ILEUM AT RESECTION OF DIFFERENT VOLUMES OF LIVER}, url={https://ojs.tdmu.edu.ua/index.php/MCC/article/view/9782}, DOI={10.11603/mcch.2410-681X.2018.v0.i4.9782}, abstractNote={<p><strong>Introduction.</strong> Removal of large volumes of liver parenchyma are complicated by postresection portal hypertension. The latter leads to the morphological rearrangement of the organs of the drainage basin portal hepatic vein, the damage to their structures, changes in the energy supply structures, which are not sufficiently investigated when damaging the ileum in the named pathological conditions.</p> <p><strong>The aim of the study –</strong> to study the features of the energy supply of the muscle of the ileum at resection of different volumes of liver parenchyma.</p> <p><strong>Research Methods.</strong> Studies were conducted on 45 white male rats, which were divided into 3 groups. The group 1 consisted of 15 intact animals, group 2 – 15 rats, in which 31.5 % of liver parenchyma was removed, 3 – 15 rats were after resection of 58.1 % of liver parenchyma. Euthanasia of experimental animals was carried out by bloodletting in conditions of thiopental anesthesia 1 month after the beginning of the experiment. The state of the energy supply of the muscle membrane of the ileum in conditions of postresection portal hypertension was studied by determining the levels of ATP, ADP and AMF in it. Histologic preparations from the ileum dyed hematoxylin-eosin, for van Gizon, Mallory, Weigert, toluidine blue. Histostereometrically determined the thickness of the muscle of the ileum, relative volumes of myocytes, stroma, damaged myocytes, stromal-myocyte relations. Quantitative values ​​were processed statistically. <strong>Results and Discussion</strong>. In rats, one month after resection, 58.1 % of the liver parenchyma was followed by enlargement of the hepatic portal vein, enlargement and widening of the mesentery veins and the visible venous vessels of the small and large intestines, splenomegaly, ascites. The revealed changes indicated the presence of portal hypertension. Mucous membrane of the empty bowel is full-blooded, edematous, with single cells of point hemorrhages. In the wall of the ileum, resection of 58.1 % of the liver parenchyma revealed dystrophy, necrobiosis of epithelial cells, myocytes, endothelial cells, stromal structures, infiltrative and sclerotic processes. With removal of 58.1 % of the volume of this organ, the relative volumes of stroma increased by 17.5 %, damaged myocytes by 20.5 times, stromal-myocyte relations – by 21.1 %, indicating significant damage to the muscle ileum. At the defeat of the ileum was detected, the levels of ATP, ADP, and AMF were expressed in the muscle, indicating a marked deterioration in the energy supply of the investigated structure.</p> <p><strong>Conclusions</strong>. Resection of large volumes of liver parenchyma leads to the development of postresection portal hypertension, marked deterioration of the energy supply of the muscular membrane, damage to the structures of the membranes and the vascular bad of the ileum. The degree of reduction of energy supply of the muscle depends on the removed volume of liver parenchyma and severity damages of the ileum structures.</p>}, number={4}, journal={Medical and Clinical Chemistry}, author={Tatarchuk, L. V. and Shulgay, A. G. and Hnatjuk, M. S.}, year={2019}, month={Jan.}, pages={11–16} }