@article{Gerush_Grigorieva_Ferenchuk_2018, title={GLUTATHIONE INFLUENCE ON BIOCHEMICAL INDICES OF BLOOD SERUM IN EXPERIMENTAL NEPHROPATHY}, url={https://ojs.tdmu.edu.ua/index.php/MCC/article/view/9552}, DOI={10.11603/mcch.2410-681X.2018.v0.i3.9552}, abstractNote={<p><strong><em>Introduction. </em></strong><em>Kidney disease is one of the most common problems of modern medicine. </em></p> <p><strong><em>The aim of the study</em></strong><em> – to determine the effect of glutathione on the change in biochemical findings of blood under conditions of experimental nephropathy.</em></p> <p><strong><em>Research Methods.</em></strong><em> Experiment was carried out on 90 male albino rats with the body weight of 0.16–0.18 kg. The animals were introduced a single intraperitoneal dose of folic acid (2</em><em>00 </em><em>or 50 mg/kg) for modeling nephropathy. Glutathione was introduced intragastrically (100 mg/kg) during 3 and 7 days after intoxication with folic acid. The concentration of creatinine, urea, albumin, total protein, activities of γ-glutamyltranspeptidase activity and alanylaminotranspeptidase weredetermined.</em></p> <p><strong><em>Results and Discussion.</em></strong><em> Under conditions of nephropathy the urea content increase by 27 % as compared with the control group on the third and by 15 % on the seventh day of the experiment was observed. The introduction of glutathione contributed to the normalization of the content of urea in the blood. An increase in the level of serum creatinine in rats with nephropathy (by using folic acid at a dose of 200 mg/kg) in 1.5 times in comparison with the control group was observed. On the seventh day the level of creatinine increased by 17 %. In the group of animals where nephropathy was caused by folic acid at a dose of 250 mg/kg, on the third day of the experiment the creatinine concentration increased 2.4 times and by 30 % on the seventh day of the study as compared with the control. Seven-day glutathione influence equates the creatinine values of experimental animals with those of the intact group. </em></p> <p><strong><em>Conclusions. </em></strong><em>Glutathione shows nephroprotective properties confirmed by a decrease in the manifestations of nephrotic syndrome and improvement of the functional parameters of the kidneys. The content of creatinine depends on the concentration of the toxicant. It can be used to diagnose the kidney condition and confirm the model of nephropathy.</em></p>}, number={3}, journal={Medical and Clinical Chemistry}, author={Gerush, I. V. and Grigorieva, N. P. and Ferenchuk, Ye. O.}, year={2018}, month={Nov.}, pages={27–32} }