Prospects for investigation of hereditary predisposition to the appearance and development of generalized periodontitis

M. I. Khomyk, H. M. Melnychuk, L. Ye. Kovalchuk

Abstract


Literature review from 2004 to 2016 years was performed. It was described methods of investigation that had been used in the study of genetic predisposition to generalized periodontitis (GP) in particular: clinic-genealogical, „twins” – method, dermatology, cytogenetic. It was analyzed the prospect of using a novel research methods of genetic markers burden on the preclinical stage development of the GP in particular: the complex investigation of the family trees, epigenetics, morphodensitometric and immunogenetic diagnostic criteria GP development.


Keywords


generalized periodontitis; functional state of genotype; metaphasic chromosomal analysis; morphodensitometric; micronuclear indices.

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DOI: http://dx.doi.org/10.11603/2311-9624.2016.4.7232

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