VITAMIN D AND DIABETES MELLITUS TYPE 2

N. V. Pasyechko, V. M. Kulchinska, L. V. Radetska, L. V. Naumova, I. V. Smachylo, A. O. Bob, I. P. Savchenko, N. I. Yarema, M. Y. Havryliuk, A. I. Balaban, O. O. Bob, M. A. Dzhula, T. I. Krytskyi

Abstract


Background. As it is established that diabetes mellitus causes metabolic disturbances of all types (first of all because of carbohydrate metabolism), affection of blood vessels, nerves, different organs and tissues. However, the influence of DM on the level of microelements is still not investigated enough. Despite the sufficient variety of medicaments, compensation of diabetes mellitus is achieved in less than 30% of patients. For this reason, the search of new ways of treatment which are aimed at the improvement of carbohydrate metabolism is an urgent issue.

Objective. The research was aimed to reveal the deficiency of 25-hydroxyvitamin D3 [25(OH)D3] and its correlation with carbohydrate metabolism.

Methods. Thirty five patients with diabetes mellitus Type 2 aged 55-74 with illness duration 2-4 years were examined. The control group included 35 healthy people of the same age and sex. Levels of 25-hydroxyvitamin D3 [25(OH)D3] were tested by means of radioimmunoassay. The level of glycated haemoglobin was tested by means of liquid chromatography.

Results. Correlation of the level of vitamin D with the degree of diabetes mellitus Type 2 compensation has been detected.

Conclusions. A clear tendency to the improvement of diabetes mellitus Type 2 compensation after medication correction with vitamin D was evidenced. 


Keywords


diabetes mellitus; vitamin D; glycated haemoglobin; glycemic control.

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References


Pankiv VI. Symposium № 156. Diabetes mellitus: definition, classification, epidemiology, risk factors. International Journal of Endocrinology 2013; № 7: 95–104.

Pankiv VI. The aim of modern treatment of patients with diabetes mellitus: add not only years to life, but life to years. Practical angiology 2011; 8 (1).

Povorozniuk VV,Balatska NI, Muts VIa, Vdovina OA. Deficiency and insufficiency of vitamin D in citizens of Ukraine. Pain. Joints. Spine 2011; 4 (04): 5–13.

Yefimov AS, Mykhalchuk LM. Deficiency of vitamin D and vascular injures at diabetes mellitus type 2. International Journal of Endocrinology 2013; 5: 10–13.

Komisarenko YuI. Deficiency of vitamin D and its role in development of breach metabolism at diabetes mellitus. Clinical endocrinology and endocrine surgery 2013; (3): 69–74.

Pittas A, Lau J, Hu F, Dawson-Hughes B The role of vitamin D and calcium in type 2 diabetes. A systematic review and meta-analysis. J Clin Endocrinol Metab 2007; 92: 2017–2029.

Pittas A, Nelson J, Mitri J, Hillmann W, Garganta C, Nathan D et al. Plasma 25-hydroxyvitamin D and progression to diabetes in patients at risk for diabetes: an ancillary analysis in the Diabetes Prevention Program. Diabetes Care 2012; 35: 565–573.

Lau S, Gunton J, Athayde N, Byth K, Cheung N Serum 25-hydroxyvitamin D and glycated haemoglobin levels in women with gestational diabetes mellitus. Med J Aust 2011; 194: 334–337.

Alzaim M, Wood R Vitamin D and gestational diabetes mellitus. Nutr Rev 2013; 71: 158–167.

Bodnar PM, Mykhalchyshyn HP, Komisarenko YuI. Endocrinology. Vinnytsia: New book 2013. 11. Kienreich K, Tomaschitz A, Verheyen N, et al. Vitamin D and cardiovascular disease. Nutrients 2013; 5(8): 3005–3021.

Povorozniuk VV, Balatska NI. Deficiency of vitamin D in population of Ukraine and risk factors of its development. Pain.Joints.Spine 2012; 4(8): 5–11.

Komisarenko YuI. Correction of the breach of metabolism in patients with diabetes mellitus type 1 and type 2 by vitamin D3. Ukrainian biochemical journal 2014; 1: 111–116.

Shvarts HIa. Deficiency of vitamin D and its pharmacological correction. Russian Journal of Medicine 2009; 7: 477.

Shupyna MY, Nechaeva HY, Lohynova EN, Shupyn DV. Alfacalcidol in the treatment of osteoporosis: influence on bone density, risk of falls and fractures. Treating doctor 2016; 04.




DOI: http://dx.doi.org/10.11603/ijmmr.2413-6077.2016.2.7021

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