The role of hypoxia and proton mechanism of parietal cells in the occurence of stress-induced and peptic ulcers

Authors

  • Ya. I. Honskyi
  • V. V. Hnativ
  • B. O. Pereviznyk
  • S. R. Pidruchna
  • I. P. Kuzmak
  • T. Y. Yaroshenko

DOI:

https://doi.org/10.11603/mcch.2410-681X.2016.v0.i4.7285

Keywords:

stress-induced ulcers, peptic ulcers, hypoxia.

Abstract

Based on experimental and clinical research, the authors revealed the preventive and therapeutic effect of continued intragastric delivery of molecular oxygen in case of stress-induced and peptic erosions and ulcers of stomach and duodenum. The hypothesis of possible role of hypoxia in the mechanism of injury of parietal cells is based on a consequence of transfer of protons from matrix of mitochondria and its further accumulation in cytoplasm. In this situation, the H+-dependent processes occur, particularly ATP synthesis and production of hydrochloric acid for which the protons are used. 

References

Bezperervna tryvala hastrointestynalna oksyhenoterapiia v abdominalnii khirurhii / Kovalchuk L.Ia., Hnativ V.V., Bedeniuk A.D., Basystiuk I.I., Husak O.M. // Materialy naukovo-prakt. konf. khirurhiv Ternopillia. – Ternopil: Ukrmedknyha, 2002. – S. 99-100.

Das D., Banerjee R.K. Effect of stress on the antioxidant enzymes and gastric ulceration // Molecular & Cellular Biochemistry.- 1993. - Vol.125, № 2. – P. 115-125.

Esedov E.M., Mamaev S.N. Effects of mono- and combined peptic ulcer therapy on lipid peroxydation and antioxidant defense in ulcerous zone // Klinicheskaia Meditsina. – 1998. - Vol.76, № 1. P. 28-31.

Hansen J.,Weiher J. Intensive Therapy under the conditions of HBO. 10th Eurropean Congress of Anaestesiology, 1998, P. 382.

Qin Y, Melse-Boonstra A, Pan X, Yuan B, Dai Y, Zhao J, et al. Anemia in relation to body mass index and waist circumference among Chinese women. Nutr J. 2013;12: 10. doi: 10.1186/1475-2891-12-10.

Lee B. J, Kim J. Y Identification of Hemoglobin Levels Based on Anthropometric Indices in Elderly Koreans. PLoS ONE.-2016. - Vol. 11 № 11: e0165622. doi:10.1371

Published

2017-02-17

How to Cite

Honskyi, Y. I., Hnativ, V. V., Pereviznyk, B. O., Pidruchna, S. R., Kuzmak, I. P., & Yaroshenko, T. Y. (2017). The role of hypoxia and proton mechanism of parietal cells in the occurence of stress-induced and peptic ulcers. Medical and Clinical Chemistry, (4), 100–104. https://doi.org/10.11603/mcch.2410-681X.2016.v0.i4.7285

Issue

Section

ORIGINAL INVESTIGATIONS