Apoptotic cell death and ways of its initiation in case of experimental obesity

M. I. Marushchak

Abstract


In the article there were studied the levels of altered apoptotic and necrotic cells of blood leukocyte suspension and their correlation with indicators of free radical oxidation, cytokine status, carbohydrate and lipid metabolism on experimental models of obesity. Methods of statistical analysis are showed that the activation of programmed cell death during experimental obesity in the rats is characterized by an increase of the percentage of annexin-positive leukocyte in 2.1 times in cell suspension. Violation of immunological reactivity together with increasing concentrations of leptin, total cholesterol and triacylglycerols levels plays f significant role in this changes. 


Keywords


obesity; apoptosis; initiation factor.

References


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DOI: http://dx.doi.org/10.11603/mcch.2410-681X.2016.v0.i4.7260

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