Correlation analysis of gas and acid-base indices of arterial blood in the pathogenesis of experimental hepatopulmonary syndrome

I. Ya. Krynytska

Abstract


The correlation analysis of indices of gas and acid-base composition of arterial blood in the pathogenesis of experimental hepatopulmonary syndrome was studied in the article. It was established a strong negative correlation between partial pressure of oxygen and AaDO2, positive moderate correlation between the plasma osmolarity and AaDO2 in animals of both experimental groups, the positive moderate correlation between the concentration of lactic acid and AaDO2 in animals with carbon tetrachloride-induced cirrhosis and strong correlation interaction between these parameters in rats the on 31st day after common bile duct ligation.


Keywords


hepatopulmonary syndrome; blood gases; correlation analysis.

References


Voronin Osoblyvosti patolohii orhaniv travlennia u khvorykh pokhyloho ta starechoho viku i efektyvnist yikh likuvannia / K. O. Voronin // Hastroenterolohiia. – 2013. – № 3 (49). – S. 56–59.

Hepatopulmonalnyi syndrom: ventyliatsiino-perfuziina funktsiia lehen, patohenez yii porushennia / O. O. Abrahamovych, M. O. Abrahamovych, S. Ia. Tolopko, M. R. Ferko // Tuberkuloz, lehenevi khvoroby, VIL-infektsiia. – 2013. – № 2 (13). – S. 52–56.

Yeshchenko A. V. Vplyv funktsionalnykh porushen biliarnoho traktu na stan pechinky v pidlitkiv / A. V. Yeshchenko // Hastroenterolohiia. – 2013. – № 2 (48). – S. 36–39.

Krynytska I. Ia. Zminy hazovoho skladu arterialnoi krovi u shchuriv z modelovanym hepatopulmonalnym syndromom / I. Ia. Krynytska // Visn. nauk. doslidzh. – 2012. – 69, № 4. – S. 72–75.

Luk’ianchuk V. D. Vplyv MIHU-2 na hazovyi sklad ta kyslotno-luzhnu rivnovahu krovi u shchuriv z hipoksychnoiu hipoksiieiu na tli hipertermii / V. D. Luk’ianchuk, N. V. Vitokhina, D. S. Kravets // Ukr. zhurn. klinich. ta lab. medytsyny. – 2010. – 5, № 3. – S. 91

Nevzorova V. A. Pechenochno-legochnyi sindrom i osobennosti ego proiavlenii pri tcirroze pecheni, sochetaiushchemsia s khronicheskoi obstruktivnoi bolezniu legkikh / V. A. Nevzorova, E. A. Kochetkova, Zh. Massard // Terapevticheskii arkh. – 2009. – № 3. – S.15–19.

Pat. Na korysnu model 63892U Ukraina, MPK A61B 17/00. Sposib vidboru krovi v eksperymenti u shchuriv / Hudyma A. A., Dobrorodnii A. V., Marushchak M. I., Dobrorodnii V. B., Koptiukh V. V. – № u 2011 03185 ; zaiavl. 18.03.11 ; opubl. 25.10.11, Biul. № 20.

Bernardi M. Disturbances of acid–base balance in cirrhosis: a neglected issue warranting further insights / M. Bernardi, S. Predieri // Liver International. – 2005. – 25. – Р. 463–466.

European convention for the protection of vertebrate animals used for experimental and other scientific purposes. – Council of Europe. Strasbourg. – 1986. – № 123. – 52 p.

Fallon M. B. Common bile duct ligation in the rat: a model of intrapulmonary vasodilatation and hepatopulmonary syndrome / M. B. Fallon, G. A. Abrams, J. W. McGrath // Аm. J. Phisiol. – 1997. – 272. – P. 779 – 784.

Lustik S. J. The hyperventilation of cirrhosis: progesterone and estradiol efects / S. J. Lustik, A. K. Chhibber, J.W. Kolano // Hepatology. – 1997. – 25. – Р. 55–58.

Rodriguez-Roisin R. Pulmonary-Hepatic vascular Disorders (PHD) / R. Rodriguez-Roisin, M. J. Krowka, Ph. Herve // Eur. Respir. J. – 2004. – 24. – P. 861–880.

Watt G. Chemical Pathology Lecture Notes / G. Watt. – Cape Town : Prentice Hall, 2011. – 454 p.

Zhang Hui-Ying Multiple pathogenic factor-induced complications of cirrhosis in rats: A new model of hepatopulmonary syndrome with intestinal endotoxemia / Hui-Ying Zhang, De-Wu Han, Zhong-Fu Zhao // World J. Gastroenterology. – 2007. – 13 (25). – P. 3500–3507.




DOI: http://dx.doi.org/10.11603/mcch.2410-681X.2016.v0.i4.7255

Refbacks

  • There are currently no refbacks.