The state of free-radical oxidation and antioxidant system at the experimental acute peritonitis associated with hypothyroidism

R. V. Verba, I. M. Klishch

Abstract


To study the influence of hypothyroidism on the course of free-radical processes and state of antioxidant system in rats with acute extensive peritonitis, the production of active forms of oxygen by mononuclear leukocytes, concentration of lipid hydroperoxides, TBA-active products, Schiff bases, SOD and catalase activity were determined. Simulation of extensive peritonitis with associated hypothyroidism led to the less obvious, than in euthyroid rats, increase of active forms of oxygen and lipid peroxidation products. Although the reduction of activity of enzymes of the first line of antioxidant defense (superoxide dismutase and catalase) was more evident.


Keywords


extensive peritonitis; hypothyroidism; free-radical oxidation; antioxidant system.

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DOI: http://dx.doi.org/10.11603/mcch.2410-681X.2016.v0.i4.7251

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